What side effects Citalopram may have?
Below you will find the most important information about possible known side effects of Citalopram.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
drowsiness, insomnia, weakness, headache, tremors, nausea, dry mouth, constipation, increased sweating.
Common side effects:
sleep disorders, general exhaustion, difficulty concentrating, memory disorders, anxiety disorders, excitement, nervousness, fatigue, increased yawning, altered dream life, confusion, changes in appetite, weight change, apathy, suicidal tendencies, sensory disturbances, pleasure disorders (libido decrease) , Abdominal pain, indigestion, vomiting, bloating, increased salivation, difficulty urinating, ejaculatory disorders, impotence, painful menstrual bleeding, skin hypersensitivity reactions such as rash and itching, blurred vision, taste disorders, muscle pain, palpitations, palpitations, hypotension.
Uncommon side effects:
euphoria, aggressiveness, allergic reactions such as cough and shortness of breath, seizures, heartbeat deceleration, elevation of liver function, photophobia, tinnitus, fainting, orgasmic disorders in women.
Rare side effects:
Reduced sodium content of the blood.
Very rare side effects:
uterine bleeding, gastrointestinal bleeding, skin bleeding, mucosal bleeding, liver inflammation, pancreatitis.
Especially at the beginning of treatment it can lead to tormenting restlessness and restlessness of limbs (akathisia).
Headache, nausea, drowsiness, sensory disturbances and anxiety may occur after the end of therapy. These complaints usually resolve within two weeks, but may last for two to three months or more. The treatment should therefore be stopped only with slow dose reduction for weeks or months.
In conjunction with taking MAO inhibitors, the life-threatening serotonin syndrome can occur with confusion, shaking, sweating, fever, and blood pressure drop to coma.
Recent studies have shown that citalopram’s work on bone formation and degradation cells is adversely affected, especially with long-term use. This can lead to increased fractures, or the development of osteoporosis.
Citalopram may cause dose-dependent arrhythmia (QT prolongation). Therefore, the maximum recommended dose for adults is 40 milligrams of citalopram daily, for elderly patients and those with reduced liver function, 20 milligrams daily.
What interactions does Citalopram show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Concomitant use of citalopram and irreversible MAO inhibitors (tranylcypromine) as well as reversible selective MAO-A inhibitors (moclobemide) or MAO-B inhibitors (selegiline) may cause life-threatening serotonin syndrome with confusion, tremor, sweating, Cause fever and hypotension to coma. Therefore, citalopram must not be given in combination with these agents. Citalopram should be given no earlier than two weeks after the end of treatment with irreversible MAO inhibitors and not earlier than one day after discontinuation of moclobemide or selegiline.
Serotonin syndrome as well as increased blood pressure or constriction of the coronary arteries may also occur when citalopram is coadministered with other agents that affect the serotonin content of the blood. These include the painkiller tramadol, the triptans (for migraine) or tryptophan (used as a sleep aid).
Administering pimozide and citalopram at the same time prolongs the QT interval and can lead to severe cardiac arrhythmia. The two active substances must therefore not be used simultaneously. The concomitant use of citalopram with other agents that alter the heart rhythm (QT prolongation) is also prohibited. In addition to antiarrhythmics such as quinidine and sotalol, these include antibiotics such as erythromycin and trimethoprim-sulfamethoxazole, some H1-antihistamines (for allergy), many neuroleptics, other psychotropic drugs, Parkinson’s drugs, malaria drugs and X-ray contrast media and various opioid analgesics.
The concomitant use of citalopram and St. John’s wort preparations should also be avoided because of the increased risk of side effects.
If the antidepressants imipramine or desipramine are given at the same time, their effects increase, so that the dose of these agents may need to be reduced by the doctor.
If beta-blockers such as metoprolol are taken at the same time, their effect is almost doubled by citalopram. Again, a dose reduction by the physician may be necessary.
In combination with anticoagulants or anticoagulants such as non-steroidal anti-inflammatory drugs, acetylsalicylic acid, ticlopidine, dipyridamole, atypical antipsychotics, phenothiazines and tricyclic antidepressants, bleeding tendency is increased.
Co-administration of lithium or tryptophan may increase the effects of citalopram.