Digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with liver disease), hepatitis, hepatonecrosis.
Central nervous system and peripheral nervous system: dizziness, headache, fatigue, anxiety, tremor, insomnia, nightmarish dreams, peripheral paralysis (anomaly of perception of pain), sweating, increased intracranial pressure, anxiety, confusion, depression, hallucinations , manifestations of psychotic reactions (sometimes progressing to conditions in which the patient can do harm to himself), migraine, fainting, thrombosis of the cerebral arteries.
Senses: a violation of taste and smell, visual impairment (diplopia, change in color perception), noise in the ears, hearing loss.
Cardiovascular system: tachycardia, heart rhythm disturbances, lowering blood pressure, flushing of blood to the skin of the face.
Hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
Laboratory indicators: hypoprothrombinemia, increased activity of hepatic transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
Urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, decreased renal nitrogen function, interstitial nephritis.
Musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia.
Allergic reactions: skin itching, urticaria, blistering accompanied by bleeding, papules forming scabs, drug fever, pinpoint hemorrhages, facial or laryngeal edema, dyspnea, eosinophilia, increased photosensitivity, vasculitis, nodal erythema, exudative erythema multiforme, syndrome Stevens-Johnson, toxic epidermal necrolysis (Lyell’s syndrome).
Other: arthralgia, arthritis, tendovaginitis, tendon ruptures, general weakness, myalgia, superinfections (candidiasis, pseudomembranous colitis), pain and burning at the injection site, phlebitis.