The following provides information on contraindications to the use of celecoxib in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Celecoxib not be used?
Celecoxib should not be used at:
- Hypersensitivity to this substance and sulfa drugs (active substances against bacteria)
- Patients who have experienced allergic reactions such as asthma, acute runny nose, nasal polyps, mucosal swelling and hives after taking acetylsalicylic acid (non-opioid analgesic) or other nonsteroidal anti-inflammatory drugs
- Heart disease due to constriction of the coronary arteries, moderate to severe myocardial insufficiency (NYHA stages II – IV.)
- calcification of brain blood vessels
- gastric ulcers or intestinal ulcers, in gastric bleeding or intestinal bleeding and in chronic inflammatory bowel disease
- severe liver dysfunction
- severe kidney damage.
In addition, women of childbearing potential should refrain from the use of celecoxib without safe contraception.
Celecoxib should only be given to celecoxib after a strict risk / benefit assessment
- significant risk factors for the occurrence of cardiovascular disease
- significant risk factors for the development of diseases in the stomach and intestine
- combination with anticoagulant drugs (anticoagulants).
Elderly patients should be monitored with extra care while receiving Celecoxib.
Some people have a deficiency in the enzyme CYP2C9, which is needed to break down celecoxib. The blood levels of celecoxib are likely to be significantly elevated in such patients. If the enzyme deficiency is known, the affected person should be treated with special medical care.
What should you watch out for during pregnancy and lactation?
There are no clinical data on the risks of using celecoxib in pregnant women. In studies on rats, however, malformations were detected. The potential risk in humans during pregnancy is unknown but can not be excluded. In addition, celecoxib can cause inhibition of labor. Celecoxib should therefore not be used during pregnancy. The same applies to breastfeeding. Here, in animal experiments, a transition of the drug into breast milk was observed.
What should be considered in children?
Celecoxib is not suitable for use in children.
Warnings and Precautions
- Because of the risk of side effects on the heart and blood vessels, the drug should be given in the lowest effective dose for as short a time as possible.
- The drug is not blood thinning enough to do without the necessary anticoagulant treatment.
- If renal function deteriorates, treatment should be discontinued.
- At the first sign of rash, mucosal damage or other signs of hypersensitivity, discontinue treatment with the drug.
- The drug may be fever and other signs
to disguise an inflammation.
- Care must be taken to ensure safe contraception during treatment with the drug.
- People with a deficiency of the enzyme CYP2C9 may need a lower dosage of the drug.
- The drug can reduce responsiveness, making it dangerous to drive or use machinery.
- Simultaneous alcohol consumption additionally reduces the ability to react.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.