What side effects can Celecoxib have?
Below you will find the most important information about possible known side effects of Celecoxib.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
sinusitis, respiratory tract infections, insomnia, dizziness, pharyngitis, runny nose, abdominal pain, diarrhea, indigestion, bloating, rash, tissue retention (edema).
Uncommon side effects:
urinary tract infections, anemia, blood potassium elevation, anxiety, depression, fatigue, blurred vision, increased muscle tension, numbness, ear noises, heart attack, heart failure, palpitations, high blood pressure, worsening of high blood pressure, coughing, shortness of breath, constipation, regurgitation, gastritis , Inflammation of the mouth, Vomiting, Hepatic impairment, Hives, Leg cramps, worsening of intestinal inflammation, Hepatic enzyme elevation, Renal value elevation, Blood urea concentration elevation.
Rare side effects:
Individual blood cell reductions, platelet reduction, movement disorder, taste disorders, stroke arterial occlusion, esophageal ulcers, gastric ulcers, small bowel ulcers, colonic ulcers, dysphagia, intestinal perforation, esophagitis, tarry stools, skin pigmentation increase, hair loss, photosensitivity. p>
Very rare side effects:
Reduction of all blood cells, confusion, delusions, epilepsy deterioration, meningitis, loss of taste, olfactory loss, hearing loss, vascular inflammation, bronchoconstriction, menstrual disorders, gastric bleeding, intestinal bleeding, acute pancreatitis, colitis, hepatitis, jaundice, liver failure, vascular swelling , severe skin reactions such as peeling skin inflammation and Stevens-Johnson syndrome, muscle inflammation, kidney failure, nephritis.
What interactions does celecoxib show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Celecoxib should not be co-administered with coagulation inhibitors (anticoagulants) such as warfarin. This can lead to bleeding with a partly fatal course.
Ciclosporin and tacrolimus, immunologic agents used in autoimmune diseases, are exacerbated in their kidney damaging effects.
Concomitant use of low-dose acetylsalicylic acid (a non-opioid analgesic) is associated with an increased risk of complications from intestinal ulcers.
Celecoxib should not be used with ACE inhibitors and angiosin II inhibitors (both antihypertensive drug groups). The combination with these cardiovascular drugs can lead to acute kidney failure.
Basically, hypotensive agents (antihypertensives) and dehydrating agents (diuretics) can be reduced in their effect by celecoxib.
Under celecoxib treatment, blood levels of dextromethorphan, a cough suppressant, are on the rise. The effect of the cough medicine can be strengthened thereby. The same applies to agents for depression (antidepressants), neuroleptics and other psychotropic drugs such as citalopram, imipramine and diazepam and for agents against cardiac arrhythmias.
Fluconazole, an anti-fungal agent, causes an increase in celecoxib concentration in the blood and may also increase the effect.
Rifampicin (tuberculosis), on the other hand, may reduce the effects of celecoxib. The same applies to carbamazepine (an antiepileptic) and barbiturates (sedatives).
The combination of methotrexate, an immunologic agent, with celecoxib should be adequately monitored by a physician. Although lithium, an anti-depression drug, is administered concomitantly, careful medical supervision is necessary.