What side effects can Cefixime have?
Below you will find the most important information about possible known side effects of Cefixime.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Uncommon side effects:
headache, hypersensitivity reactions (itching, redness, rash, hives, medicated fever, facial swelling such as angioedema, anemia such as hemolytic anemia, nephritis, in the worst case, allergic shock); transient changes in the blood count, such as leucopenia, increased white blood cells (eosinophilia), platelet reduction (thrombocytopenia), or granulocyte depletion (agranulocytosis); Liver dysfunction, increase in liver function (transaminases); Renal value increase (serum urea increase, serum creatinine increase)
Rare side effects: dizziness, abdominal pain, nausea and vomiting, loss of appetite, diarrhea, blood clotting disorders
Very rare side effects and isolated cases:
Syndrome of scalded skin (Lyell’s syndrome), skin rash with severe general symptoms (Stevens-Johnson syndrome), hepatitis, gall bladder, jaundice, hyperactivity, seizures (increased susceptibility to epilepsy)! !!!
Side effects without frequency:
stomach depressions, flatulence
Long-term treatment with cefixime may cause invasion of the large intestine with insensitive (resistant) bacteria or fungi. This can subsequently lead to an intestinal inflammation with diarrhea (pseudomembranous colitis). Treatment with cefixime should be discontinued immediately and continued with appropriate antibiotics such as vancomycin.
Long-term and repeated use of cefixime may lead to secondary infections (superinfections) with insensitive (resistant) bacteria or yeast fungi. In addition, with cephalosporins such as cefixime, which are structurally related to penicillins, cross-allergies must be expected.
What interactions does Cefixime show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
If aminoglycoside antibiotics or the antibiotics polymyxin and colistin as well as high-dose diuretics (dehydrating agents) from the group of loop diuretics are administered together with cefixime, the kidney-damaging effect of these drugs can be increased.
The combination of cefixime with anticoagulants (anticoagulants and platelet aggregation inhibitors) may prolong their effects. This increases the risk of bleeding.
The co-administration of cefixime and nifedipine, an antihypertensive agent, potentiates the effects of cefixime.
Standard laboratory tests for the determination of protein and sugar content in urine can be falsified by the use of cefixime.