What side effects can Cefaclor have?
Below you will find the most important information about possible known side effects of Cefaclor.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Uncommon side effects:
Hypersensitivity reactions (itching, redness, rash, hives, drug fever, facial swelling such as angioedema, swelling around the body, anemia such as hemolytic anemia, nephritis, in the worst case, allergic shock); transient changes in the blood count, such as white blood cells (leukopenia), increased white blood cells (eosinophilia), platelet deficiency (thrombocytopenia) or granulocyte depletion (agranulocytosis); Hepatic impairment; Liver value increase (transaminases); Renal value increase (serum urea increase, serum creatinine increase)
Rare side effects:
abdominal pain, nausea and vomiting, loss of appetite, diarrhea
Very rare side effects and isolated cases:
Syndrome of scalded skin (Lyell’s syndrome), skin rash with severe general symptoms (Stevens-Johnson syndrome), hepatitis, gall blight, jaundice
Side effects without frequency:
Depending on the dose used, the following side effects may occur: gastric pressures, loose stools, bloating, rashes, neuronal disorders (sleep disorders, dizziness, nervousness, hyperactivity, confusion, hallucinations, increased tendency seizures (epilepsy), low blood pressure, tachycardia, shortness of breath, high blood pressure, joint problems, skin reactions (such as rash, exfoliative dermatitis), vaginal infections, protein in the urine (proteinuria)
During long-term treatment with Cefaclor, the colon may be affected by insensitive (resistant) bacteria or fungi. This can be followed by an intestinal inflammation with diarrhea (pseudomembranous colitis). Treatment with cefaclor should be stopped immediately and continued with appropriate antibiotics such as vancomycin.
Long-term and repeated use of Cefaclor may lead to secondary infections (superinfections) with insensitive (resistant) bacteria or yeast fungus. In addition, with cephalosporins such as cefaclor, which are structurally related to penicillins, cross-allergies must be expected.
What interactions does Cefaclor show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Antibiotics that inhibit the growth of bacteria can reverse the effects of cephalosporins. Cefaclor should therefore not be combined with active ingredients such as tetracyclines, erythromycin, sulfonamides or chloramphenicol.
The effect of Cefaclor is enhanced when taken with the ointment Probenecid.
Cefaclor leads to an increase in the effectiveness of aminoglycoside antibiotics, which can also lead to increased side effects such as kidney damage. When combined with anticoagulants (anticoagulants and antiplatelet agents), their effects are prolonged, increasing the risk of bleeding.
Standard laboratory tests for the determination of protein and sugar content in urine can be falsified by the use of Cefaclor.