manufacturer: AstraZeneca GmbH
active ingredient: bicalutamide
Dosage Form: Filmtablette
Very common side effects:
Chest distension, enlargement of the breast, hot flashes, decreased libido, impotence to impotence, kidney and urinary disorders.
Common side effects:
itching, rapid fatigue, nausea, diarrhea, liver dysfunction, constipation, anemia, dizziness, drowsiness, rash, sweating, hirsutism, weight gain, diabetes mellitus, edema, pelvic pain, general pain, chills. !! !!
Occasional side effects:
Hypersensitivity reactions such as swelling and rash, lung disease, loss of appetite, dry mouth, indigestion, gastrointestinal discomfort, flatulence, gall bladder disorders, sleep disorders, respiratory distress, nocturnal urination, hair loss, blood sugar level, weight loss, Abdominal pain, chest pain, headache, neck pain, back pain, vomiting.
Rare side effects:
Very rare side effects:
cardiac pain, cardiac arrhythmias, myocardial insufficiency, ECG changes, platelet count reduction.
There is a possibility that certain drugs will delay the breakdown of bicalutamide. Such agents are, for example, cimetidine, ketoconazole, terfenadine, astemizole, cisapride and cyclosporin. This may result in an increased and prolonged effect of bicalutamide.
Anticoagulants of coumarin type, such as warfarin, may be potentiated in their action. Therefore, a precise monitoring of the coagulation values is required (laboratory control).
A testosterone deficiency can cause cardiac arrhythmias (prolongation of the QT interval). Therefore, the physician will only prescribe bicalutamide with substances known to prolong the QT interval, or to cause torsades de pointes, only after careful consideration of the benefit-risk balance. These agents include class I antiarrhythmics (such as quinidine, disopyramide) or class III (such as amiodarone, sotalol, dofetilide, ibutilide), the drug substitute methadone, the antibiotic moxifloxacin and neuroleptics.