Following is information on contraindications to the use of Carvedilol in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Carvedilol not be used?
Carvedilol must not be used at
- Hypersensitivity to the active substance
- slow heart rate (resting heartbeat before treatment under 50 beats per minute)
- low blood pressure (hypotension)
- cardiovascular shock
- severe diseases of the cardiac conduction system (such as AV block II and III degrees, sinus node syndrome)
- untreated adrenal cortical tumor (pheochromocytoma)
- Asthma and Chronic Obstructive Pulmonary Disease
- concomitant administration of calcium channel blockers administered via the veins (such as verapamil, diltiazem)
- Metabolic Acidosis
- liver dysfunction
- concomitant use of MAO inhibitors against depression
- Pulmonary embolism.
very strong heart muscle weakness (stage III-IV)
Carvedilol should only be used after careful consideration of the benefits, risks and strict medical control of:
- Acute Inflammatory Heart Disease
- severe forms of circulatory disorders of the arms and legs
- Patients with chronic myocardial insufficiency treated with digitalis.
- concomitant use of cimetidine
- Patients with allergy treated as part of desensitization.
- Patients with psoriasis or family members suffering from psoriasis
- previously experienced severe allergic reactions to, for example, other agents or contrast agents in radiographic studies
- Constrictions on the heart valves or vessels leading away from the heart.
- concomitant treatment with alpha-1 receptor antagonists, alpha-2 receptor agonists or anesthetics
- weak conduction disturbances in the heart (AV block I. degree)
- Diabetes with high blood glucose levels
- impaired kidney function
- reduced flow of tears
- strict fasting
- not permanently elevated blood pressure (labile hypertension) or high blood pressure in the context of other diseases
What should you watch out for during pregnancy and lactation?
No use should be made during pregnancy and breastfeeding.
What should be considered in children?
In children and adolescents, the application should be made only after careful medical benefit-risk assessment.
Warnings and Precautions
- There is a risk of myocardial infarction in the event of a sudden cessation of therapy, so it may only be discontinued gradually.
- Before anesthesia, the doctor should be informed about the intake.
- Diabetics should check their blood sugar levels frequently, and the signs of hypoglycaemia can no longer be recognized as such (obfuscation).
- Contact lens wearers should keep in mind that lessening of tears may occur.
- Regular medical checks are required. Treatment should be given to an experienced physician (internist, cardiologist).
- At baseline, worsening of the heart (especially increased fluid retention) is possible.
- If the heartbeat slows down, the doctor should reduce the dose.
- The drug is on the Doping List and should not be used during sports competitions.
- The ability to drive or operate machinery may be impaired. This applies to a greater extent at the beginning of treatment and in conjunction with alcohol.
Sometimes medications release allergic reactions.
If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.