What side effects can Carvedilol have?
Below you will find the most important information about possible known side effects of Carvedilol.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
The side effects occur in different ways and frequencies depending on the dosage and the field of application.
Heart muscle weakness
Very common side effects:
Dizziness, headache (usually at the beginning of treatment and usually weak), weakness, fatigue.
Common side effects:
blurred vision, slow heart rate, drop in body position, low blood pressure, fluid retention (edema), excess blood, fluid retention in the body, nausea and vomiting, diarrhea.
in patients with diabetes:
weight gain, excess cholesterol in the blood, excess blood sugar, worsening of blood sugar regulation.
Uncommon side effects:
Fainting including precursors to it, total AV block, worsening of heart muscle weakness (especially during the adjustment phase).
Rare side effects:
Changes in the blood count (lack of platelets and white blood cells), decreased pumping capacity of the heart (at the dose setting).
in patients with general vascular disease and / or renal dysfunction:
abnormal renal function and renal failure.
high blood pressure and angina pectoris
Common side effects:
dizziness, headache, fatigue, decreased lacrimation (especially with contact lens wearers), eye irritation, slow heart rate, drop in blood pressure on body position change, asthma, shortness of breath (in patients who tend to) , Nausea, abdominal pain, diarrhea, body aches,
Occasional side effects:
Sleep disorders, nightmares, depression, hallucinations, confusion, nervous disorders in the arms and legs, blurred vision, fainting, impaired circulation in the arms and legs (cold hands and feet, blood vessel obstruction, deterioration of intermittent claudication (claudication intermittent), impaired circulation of fingers and toes (Raynaud’s syndrome), AV block, attacks of angina pectoris (including chest pain), complaints of cardiac insufficiency, water retention in arms and legs, constipation, vomiting, impotence, skin reactions (allergic rash, Skin inflammation, hives, itching), psoriasis-like symptoms, exacerbation of psoriasis.
Rare side effects:
stuffy nose, dry mouth, urinary disorders.
Very rare side effects:
elevation of liver function (ALAT, ASAT, gamma-GT), changes in the blood count (lack of platelets and white blood cells), psychosis, general allergic reactions.
Isolated side effects:
transient urinary incontinence (in women).
Side effects without frequency:
Dizziness and headache are very common in all patients, especially at the beginning of treatment. High blood pressure and angina pectoris patients also often suffer from fatigue, slow heart rate, low blood pressure due to changes in body position and fainting.
An asthma-like shortness of air has occurred in patients with previous lung diseases.
Beta-receptor blockers may cause psoriasis in some cases, worsening their symptoms or causing psoriasis-like skin conditions.
In rare cases, an overt diabetes (latent diabetes mellitus) may appear or worsen a preexisting diabetes. Warning signs of hypoglycaemia such as palpitations and muscle tremors (tremor) can be alleviated, so that they are no longer recognizable as signs of disease (obfuscation). Therefore, regular blood sugar level checks are required.
What interactions does Carvedilol show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Carvedilol may increase the effect of other antihypertensive agents, leading to excessive blood pressure drop. This applies, for example, to the use with other beta-blockers, vasodilators, nitrates, water excretion agents (diuretics), narcotics, calcium antagonists (such as amiodarone, verapamil and diltiazem), neuroleptics and other psychotropic drugs, and alcohol. < similarly, carvedilol may increase the effect of anti-arrhythmic drugs (antiarrhythmic drugs), leading to cardiac dysfunction.
When used concomitantly with insulin or other agents used to treat diabetes, their effects may be exacerbated or prolonged. Warning signs of hypoglycaemia such as palpitations and muscle tremors (tremor) can be alleviated, so that they are no longer recognizable as signs of disease (obfuscation). Therefore, regular blood sugar level checks are required.
Combining carvedilol with brain-lowering antihypertensive agents such as reserpine, methyldopa, guanethidine, guanfacine, and clonidine or MAO inhibitors may result in a greater decrease in heart rate and delay in cardiac conduction / p>
For additional treatment with clonidine, it may only be discontinued gradually after the administration of the beta-receptor blocker has been stopped a few days previously.
The vasoconstrictor effect of ergot alkaloids can be increased by concomitant use of carvedilol, which increases the risk of circulatory disorders in the limbs.
Carvedilol may reduce the effects of corticosteroids, rifampicin or acetylsalicylic acid.
Carvedilol may prolong and enhance the effects of other agents. These include muscle relaxants, digoxin and cyclosporine. Close medical supervision is required. The same applies to the use of dihydropyridines.
The combination of carvedilol with non-steroidal anti-inflammatory drugs, estrogens and corticosteroids weakens the effects of carvedilol.
Barbiturates, rifampicin, cimetidine, ketoconazole, fluoxetine, haloperidol, verapamil and erythromycin alter the metabolism and thus the mode of action of carvedilol in different ways. Close medical supervision of the carvedilil values is recommended here.
Sympathomimetics in combination with carvedilol can lead to a rapid and very high blood pressure increase while reducing the number of heartbeats.