manufacturer: Berlin-Chemie AG / Menarini
active substance: Nebivolol
dosage form: tablet
Nebivolol must not be used with
- Hypersensitivity to the active substance or other beta-blockers
- impaired liver function
- heart failure
- Slow heartbeat (resting heartbeat before treatment under 50 beats per minute)
- low blood pressure (hypotension) with a systole value below 90mm Hg
- cardiovascular shock
- severe diseases of the cardiac conduction system (such as AV block II and III degrees, sinus node syndrome)
- untreated adrenal cortical tumor (pheochromocytoma)
- severe forms of circulatory disorders of the arms and legs
- Asthma and lung disease with chronic constriction of the airways.
- concomitant use of vascular calcium channel blockers (such as verapamil or diltiazem)
- Metabolic Acidosis.
Nebivolol should only be used after careful consideration of the benefits, risks and strict medical control of:
- weak conduction disturbances in the heart (AV block I. degree)
- Circulatory disorders of the fingers and toes (Raynaud’s syndrome)
- impaired kidney function
- Patients with psoriasis or family members suffering from psoriasis
- concomitant use of anesthetics.
What should you watch out for during pregnancy and lactation?
Nebivolol, like all beta-blockers, reduces blood flow to the suckler cake and can therefore be detrimental to the unborn baby. The active ingredient should therefore not be used during pregnancy.
In animal studies, nebivolol passed into breast milk. Since one does not know whether this is also the case in humans, the application of the active substance during breastfeeding should be avoided.
What should be considered in children?
The active substance should not be used in children and adolescents.
- The reactivity may be diminished by dizziness or tiredness. When driving and operating machinery, special care should be taken.
- The drug should not be discontinued suddenly, but in slowly reduced doses.
- The drug should be discontinued 24 hours before a planned operation. The anesthetist should be informed about the intake.
- The drug can reduce the sensitivity
against allergenic agents and the severity of allergic reactions
- If the heart rate drops below 50 to 55 beats per minute, the dosage of the medication must be reduced by the doctor.
- At the beginning of treatment for a heart failure with the drug, the patient must be carefully monitored by a doctor.
- The drug contains lactose (milk sugar) and is therefore not suitable for patients with sugar use disorders.
Medicines can cause allergic reactions. Signs can be:
Redness of the skin, runny nose, itching, mucosal swelling, itching and redness of the eyes,
Narrowing of the respiratory tract (asthma). In rare cases it can cause allergic shock with unconsciousness
If you notice signs of an allergic reaction, inform a doctor immediately.