Bisoprolol contraindications and warnings


The following provides information on contraindications to the use of bisoprolol in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should bisoprolol not be used?

The active substance must not be taken at

  • Hypersensitivity to bisoprolol or other beta-blockers
  • inadequately treated myocardial insufficiency (decompensated heart failure)
  • shock caused by heart failure (cardiogenic shock)
  • Irritations in the heart (sinus node syndrome), pathological slowing of the heartbeat (bradycardia), interruption of stimulation around the sinus node (sinoatrial block) or severe irritant conduction disturbances to the heart muscle (AV block II and III degrees)
  • Patients with low blood pressure (with a systole value below 100 mmHg)
  • severe bronchial asthma or severe, chronic lung disease
  • Circulatory disorders in the late stages of peripheral arterial occlusive disease (“intermittent claudication”) or Raynaud’s syndrome
  • Disorders of the acid-base balance or overacidification of the body (metabolic acidosis)
  • untreated disease of the adrenal medulla (pheochromocytoma
  • co-administration of MAO inhibitors (for depression).

Only after careful risk-benefit assessment by the physician may the drug be given at

  • Patients with convulsions of the bronchial muscles (bronchospasm)
  • Simultaneous treatment with nasal condiments that are inhaled
  • Diabetes (diabetes mellitus) with high blood glucose levels
  • hyperthyroidism
  • mild cardiac arrhythmias (grade I AV block)
  • the skin disease psoriasis in your own medical history or in the family
  • impaired kidney function
  • Frequent recurrent cardiac circulatory problems with tightness (Prinzmetal’s angina)
  • simultaneously with ongoing desensitization therapy (therapy to reduce allergic reactions or allergies).

What should you watch out for during pregnancy and lactation?

There are no studies on the treatment of pregnant or nursing mothers with bisoprolol. Therefore, the physician will weigh the pros and cons of treatment with the drug strictly. There are indications that the active ingredient reduces the blood flow to the baby’s stomach (placenta) and can thus lead to growth disorders in the child.

Bisoprolol passes into breast milk. In order not to harm the baby, bisoprolol is therefore not recommended in breast-feeding.

What should be considered in children?

The active substance bisoprolol is not suitable for children.

Warnings and Precautions

  • Therapy with the drug should not be stopped suddenly, but at a slowly reduced dose for seven to ten days.
  • At the beginning of treatment, the patient must be carefully monitored by a doctor. Above all, blood pressure, heartbeat, cardiac conduction disorders and a possible worsening of cardiac insufficiency must be checked by the doctor.
  • Warning signs of hypoglycaemia (eg accelerated heartbeat, muscle tremors) can be suppressed by the drug in diabetics. Therefore, regular blood glucose monitoring is necessary during treatment.
  • The drug is sometimes considered a drug and is in sports where concentration and peace of mind play a role (for example, shooting, fencing, aviation, alpine skiing) prohibited.
  • During treatment with the drug, the patient should regularly check his blood pressure.
  • Especially at the beginning of the treatment or during a change of preparation, the reaction capacity may be reduced. As a result, driving a car, operating machines and working without a secure hold can be dangerous. This is especially true in conjunction with alcohol.
  • The drug reduces the formation of tear fluid, which may affect the wearing of contact lenses.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.