Baclofen contraindications and warnings


Following is information on contraindications to the use of baclofen in general, pregnancy & breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should baclofen not be used?

Baclofen must not be used in case of hypersensitivity to the active substance, severe renal impairment, epilepsy or other seizure disorders.

Baclofen may only be used after a risk-benefit assessment by a physician and under his control.

  • impaired renal function (dose should be reduced here)
  • severe liver dysfunction
  • Damage to the brain blood vessels
  • Gastric and duodenal ulcers
  • Disorders of the respiratory function
  • bladder dysfunction
  • Confusion, Parkinson’s disease and severe mental illness
  • Acute poisoning with alcohol or sleeping pills
  • Nerve damage in the brain that affects certain movement nerves (called bulbar paralysis) and certain spinal cord diseases with shoulder-arm paralysis (syringomyelia).

The injection of baclofen directly into the cerebrospinal fluid (intrathecal) should not occur with slow circulation of cerebrospinal fluid or with impaired or diminished reflexes.

For the treatment of seizures in diseases of the abdomen baclofen is not suitable for use in rheumatic disorders, Parkinson’s disease or brain-related disorders.

What should you watch out for during pregnancy and lactation?

During pregnancy, especially in the first three months, baclofen should be taken only after careful consideration. The active ingredient can reach the unborn child through the placenta. So far, however, no harm has been observed in unborn children.

Although baclofen passes into breast milk, no complications are expected under normal circumstances. The dose should be kept as low as possible while breastfeeding.

What effect on pregnancy and lactation the drug has when administered in the spinal fluid (intrathecal), you do not know. Therefore, this form of application should be omitted.

What should be considered in children?

Baclofen is also suitable for the treatment of children. Depending on your age and body weight, you will receive a suitable dosage.

However, the administration of baclofen to the cerebrospinal fluid has not been studied in children and should therefore be avoided in patients under 18 years of age.

Warnings and Precautions

  • In patients with liver disease, liver function must be checked regularly during treatment.
  • Diabetics must regularly check their blood sugar levels during treatment.
  • No alcohol should be drunk during treatment as this may have unpredictable effects.
  • The treatment must be stopped at a slowly reduced dosage.
  • The drug interferes with responsiveness to the extent that driving and operating machines are dangerous.
  • The drug may interfere with tests for liver enzyme levels in the blood.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.