Following is information on contraindications to the use of sulfasalazine in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should not Sulfasalazine be used?
Sulfasalazine should not be taken for the following conditions:
- Hypersensitivity to sulfonamides and salicylates
- intestinal obstruction
- severe liver or kidney dysfunction.
- congenital disorder in the formation of the red blood pigment hemoglobin (porphyria)
- Diseases of the blood-forming organs
- Erythema exudative multiforme (inflammatory skin disease)
- Lack of white blood cells and platelets.
Sulfasalazine should only be taken with careful medical consideration of benefits and risks in the following conditions:
- mild liver or kidney dysfunction.
- Tendency to allergies or asthma
- Hypersensitivity to sulfonylureas (to lower blood sugar in diabetes)
- Deficiency of the enzyme glucose-6-phosphate dehydrogenase (risk of anemia due to red blood cell damage).
What should you watch out for during pregnancy and lactation?
Sulfazalasin should not be taken during the first trimester of pregnancy as it may damage the baby.
Women who want to have children should, if possible, await a disease-free phase at the beginning of pregnancy, in which no or as few medicines as possible are needed. Inflammatory bowel disease should be better avoided by using the similar mesalazine, which consists only of the active component of sulfasalzine (5-aminosalicylic acid).
Sulfasalzine can lead to deficiency of the vitamin folic acid, which is associated with severe malformations of the child. Women who want to have children should therefore take folic acid regularly while taking sulfasalazine.
Men who wish to conceive should temporarily discontinue sulfasalazine after consultation with the physician as it interferes with sperm maturation. It then takes about three months for the sperm maturation to normalize.
Sulfasalazine and Its Components Sulfapyridine and 5-aminosalicylic acid pass into breast milk. Sulfasalazine should only be taken under strict medical consideration of benefits and risks during breast-feeding.
What should be considered in children?
Sulfasalazine should not be used in children under the age of two years.
Warnings and Precautions
- Gastro-resistant tablets should not be crushed or broken before swallowing.
- Ensure adequate fluid intake.
- If there is an increase in rash, including blistering, treatment must be stopped immediately and never restarted.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.