About Azulfidine

3.5 rating based on 8 ratings
Rating: 3.3 Reviews: 8
About Azulfidine

Sulfasalazine is used in inflammatory bowel disease to relieve inflammation. Sulfasalazine is particularly suitable for the treatment of ulcerative colitis. The active substance is used both in acute episodes of disease and in long-term treatment.

What is the purpose of this ingredient?

  • Relieve inflammation in the intestine
  • Relieve pain and inflammation in joints.

This is how Sulfasalazine works

Below you will learn more about the fields of application and the mode of action of sulfasalazine.
Please also read the information on the drug groups anti-inflammatory, aminosalicylates, to which the active ingredient sulfasalazine belongs.

Applications of the active substance sulfasalazine

Sulfasalazine is used in inflammatory bowel disease to relieve inflammation. Sulfasalazine is particularly suitable for the treatment of ulcerative colitis. The active substance is used both in acute episodes of disease and in long-term treatment.

Sulfasalazine is also considered a basic therapeutic in the treatment of rheumatoid arthritis, which is one of the inflammatory rheumatic diseases, as it can also relieve the inflammatory symptoms.

Sulfasalazine can be used in the form of tablets but also as a suppository or clysma.

For the following application areas of Sulfasalazine , in-depth information is available:

  • inflammation
  • chronic inflammatory bowel disease
  • inflammatory rheumatic diseases

mode of action of sulfasalazine

Sulfasalazine belongs to the group of antiphlogistics and especially to the aminosalicylates. The active substance is mainly split in the large intestine by intestinal bacteria into its active ingredients 5-aminosalicylic acid (mesalazine) and sulfapyridine. The exact mode of action is not yet known, but 5-aminosalicylic acid is the effective substance.

5-aminosalicylic acid has anti-inflammatory activity by blocking the enzyme lipoxygenase necessary for the formation of leukotrienes. Leukotrienes are endogenous substances that sustain inflammation in the tissue. In addition, 5-aminosalicylic acid also appears to interfere with the formation and degradation of prostaglandins, which also play an important role in inflammatory processes. In addition, it is believed that sulfasalazine and its components suppress various immune responses. Immune reactions play an important role in inflammatory reactions.

In addition, sulfasalazine has antibacterial properties, that is, it inhibits certain bacteria from growing. This effect is particularly important for the treatment of acute disease relapses, which are likely to be supported by the influence of bacteria.

All these properties of sulfasalazine cause the intestinal lining to heal and new tissue to form. Since especially the surface of the intestinal mucosa is responsible for the digestion, after successful therapy the intestine can digest food again and the stool normalises itself.

In the case of inflammatory rheumatic diseases, the anti-inflammatory effect is used to reduce and delay pain, restriction of movement and inflammation-induced tissue remodeling, for example on the inner joint surface.

Potential Azulfidine side effects may include:

Effect
Percentage

Azulfidine used to treat the following diseases:

Disease
Percentage

21%

  1. Carl M. Sloan says:
    3.5 rating

    Nausea after taking MTX weekly began about 8 years after the onset of the disease. The medications MTX and Azulfidine have now been discontinued for 2 months and there is still no significant pain in the joints, except for occasional relapses.

  2. Ana M. Wheelock says:
    3.0 rating

    Azulfidine for Arthritis

    Drug has triggered severe depression, skin rash on hands, difficulty swallowing, throat mucous membranes attacked – discontinued after 4 weeks with no effect

  3. Phillip T. Keller says:
    2.5 rating

    Azulfidine for Arthritis

    Dizziness after taking, mental problems. Therefore, the drug discontinued after 4 months.

  4. Lisa H. Barnes says:
    3.5 rating

    Azulfidine for Arthritis

    severe hair loss, itchy rash, edema under eyes and eyelid, dehydration, feeling unwell

  5. Kathryn J. Thompson says:
    3.0 rating

    Azulfidine for Ulcerative colitis

    until September 2007 taking Tamoxifen (since March 2006). Due to strong side effects (sweats, tachycardia, etc.) Arimidex was prescribed. After taking Arimidex after 4 weeks extreme joint pain. Falling in the arms, morning stiffness, all limbs arm, legs hurt. no improvement by medication. Additionally for a month herniated disc LWS.

  6. Tammy D. McGhee says:
    3.5 rating

    Azulfidine for Ulcerative colitis

    I can not remember the tolerability or side effects, since I was still very young and it is already several years ago. Anyway, I do not need medication anymore today !!!

    Side effects: No side effects
  7. Thomas N. Munguia says:
    4.0 rating

    The disease Bechterew’s disease can be almost completely suppressed with this drug for me. Pain in the morning in the back or Achilles tendons only slightly and only after previous strong sports activities available (football active). Iris on the left eye has completely disappeared. Dose: 1 x 2 tablets daily Adverse reactions: none (except the known adverse reaction that the male is no longer capable of producing while taking azulfidine)

    Side effects: No side effects