Avonex contraindications and warnings


The following provides information on contraindications to the use of interferon beta-1a in general, in pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Interferon beta-1a not be used?

Interferon beta-1a must not be used, at

  • Allergy to this ingredient
  • progressive multiple sclerosis without relapses
  • severe depression with suicidal risk.

Interferon beta-1a must be administered to

    only after a medical risk-benefit assessment

  • Heart disease such as heart failure or cardiac arrhythmia (even in history), because the flu-like side effects of the drug are an additional burden
  • severe liver dysfunction
  • severe renal impairment
  • severe bone marrow damage
  • Diseases of the brain such as seizures (epilepsy), which are insufficiently treatable with antiepileptic drugs
  • Disorders of thyroid function.

What should you watch out for during pregnancy and lactation?

There are only a few cases of interferon beta-1a use during pregnancy. Available evidence suggests that there may be an increased risk of sudden miscarriage. Therefore, a start of therapy during pregnancy is prohibited. Women of childbearing potential should use effective contraception during treatment. Patients who become pregnant or are planning to become pregnant while receiving interferon beta-1a should be advised by the doctor about the potential risk to their child and treatment should be considered.

It is unknown whether interferon beta-1a is excreted in human breast milk. However, as there is a possibility that serious side effects may occur in breastfed children, either stop breastfeeding or discontinue treatment during breastfeeding.

What should be considered in children?

The administration of interferon beta-1a to children and adolescents under the age of 16 has not been adequately studied in studies. Therefore, the use of the drug in patients of this age group is prohibited.

Warnings and Precautions

  • Women of childbearing potential should take appropriate contraception measures during treatment. Before the start of therapy, pregnancy must be excluded by a doctor.
  • In order to avoid skin damage, injection of the drug should only be carried out after thorough disinfection and with a constant change of injection site.
  • For long-term use, the blood picture, liver, kidney and thyroid function should be regularly monitored by a doctor.
  • For depression and suicidal thoughts, the patient should be closely monitored by the doctor during treatment.
  • Patients with convulsions and heart disease should be monitored carefully by the doctor when taking the medicine.
  • In the event of severe liver and kidney damage as well as severe alcohol abuse, medical supervision of the treatment is necessary.
  • If transitioning from relapsing into progressive multiple sclerosis, discontinue treatment with the drug.
  • Responsiveness may be impaired, and thus the ability to drive and use machines.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.