Atorvastatin contraindications and warnings

Contraindications

The following is information on contraindications to the use of atorvastatin in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Atorvastatin not be used?

Atorvastatin should not be used at:

  • Hypersensitivity to atorvastatin
  • Liver disease or a permanent increase in blood liver enzymes
  • Skeletal muscle disease with muscle fiber destruction or an increase in blood levels suggestive of it.

Furthermore, atorvastatin should only be used with caution and only after a careful risk-benefit assessment at

  • People over 70 years old
  • Alcohol Abuse
  • favorable factors for a muscle disorder such as
    • renal dysfunction
    • thyroid
    • hereditary muscle disorders in personal history or family
    • muscle damaging effects from an earlier ingestion of a fibrate or statin
    • Situations in which increased blood levels of the drug may occur, for example, in Asian patients, liver or kidney dysfunction, or concomitant use of other agents such as ciclosporin (for organ rejection) and some AIDS agents from the HIV-1 protease inhibitor group
    • simultaneous use of fibrates.

What should you watch out for during pregnancy and lactation?

Atorvastatin should not be taken during pregnancy and breast-feeding. If atorvastatin is taken during pregnancy, a close examination of the unborn child with ultrasound is recommended. An abortion is not required. If you wish to have children Atorvastatin should be discontinued after consultation with the doctor in good time before the beginning of the pregnancy.

In animal experiments atorvastatin was found in the same concentrations in the milk as in the blood. Whether this is the same in humans has not been investigated. In any case, should not be treated with the drug while breastfeeding.

Because vascular calcification and high cholesterol levels are chronic diseases, discontinuing atorvastatin for the duration of pregnancy has little impact on the success of long-term therapy.

What should be considered in children?

Use in children should only be done by a specialist! Currently there is only therapy experience in a small number of children between the ages of four and 17 with severe hereditary homozygous hypercholesterolemia. However, no data was collected on the effects of atorvastatin therapy on childhood development during the treatments.

Warnings and Precautions

  • If any of the enzymes in the blood that indicate muscle damage increase more than fivefold when treated with the drug, the clinician should discontinue therapy or reduce the dose.
  • If the enzymes in the blood that indicate liver damage more than tripled when treated with the drug, the clinician should discontinue therapy or reduce the dose.
  • If you experience difficulty in breathing, coughing, weight loss, exhaustion and fever, discontinue treatment.
  • If a patient already has risk factors for the development of diabetes, the blood sugar must be checked regularly during treatment.
  • If there is persistent muscle weakness despite the end of treatment, this must be reported immediately to the doctor.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.