What side effects can Atorvastatin have?
Below you will find the most important information about possible known side effects of atorvastatin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects: constipation, bloating, indigestion, nausea, diarrhea, allergic reactions, insomnia, headache, drowsiness, skin sensations such as tingling, skin hypersensitivity, rash, itching, muscle aches, joint pain, languor, pain in the skin Chest, back pain, water retention in the legs, blood creatine kinase concentration increase.
Uncommon side effects:
loss of appetite (anorexia), vomiting, platelet deficiency, hair loss, blood sugar increase, blood sugar, pancreatitis, memory loss, nerve disorders, ear noises, hives, inflammatory muscle diseases (myopathy), impotence, malaise, weight gain, blood elevation ( Transaminases, transient), blood creatine kinase concentration increase (transient).
Rare side effects:
inflammation of the liver, jaundice with bile accumulation, inflammatory muscle diseases, rhabdomyolysis (disintegration of striated skeletal muscle).
Very rare side effects:
Hypersensitivity reactions, facial swelling (angioneurotic edema), blistering rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), acute memory loss, muscle decay due to an autoimmune reaction.
A hypersensitivity reaction to atorvastatin may include rash, joint pain, joint inflammation, photosensitivity, changes in specific blood levels (reduction in blood cells, increased erythrocyte sedimentation rate), vascular inflammation, depressive moods, depression, neuropathy, sexual disorders, hair loss , Erectile dysfunction, damage to the alveoli (interstitial lung disease) and sleep disorders.
All representatives of the drug group of statins seem to have a harmful effect on the nerves in common. In addition to rare memory disorders, as they are typical of all statins, atorvastatin can also show nightmares. Otherwise, the side effects occur especially on the legs. Numbness, burning sensations or muscle twitching are the signs. For such symptoms, treatment with a statin should be stopped immediately. Diabetics are especially at risk because the doctor frequently associates the described symptoms with nerve damage due to diabetes (diabetic neuropathy) and the causative statin is not discontinued.
Like all statins, atorvastatin may increase blood sugar levels and promote the development of blood sugar (diabetes mellitus). Frequency is dependent on the presence or absence of other risk factors, such as pre-existing excess blood sugar, obesity, high blood pressure, and the extent of the lipid metabolism disorder.
During or after treatment, muscle atrophy may very seldom occur due to an autoimmune reaction. Signs of persistent muscle weakness persist despite the end of treatment. Such a muscle weakness must be communicated to the doctor immediately.
What interactions does atorvastatin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Taking atorvastatin with anticoagulants (oral anticoagulants) such as warfarin prolongs the blood clotting time and may cause bleeding.
When taken together with digoxin (for heart failure), the digoxin concentration in the body increases, which may be accompanied by increased side effects of the heart remedy.
The risk of muscle disease increases when atorvastatin is taken with agents that suppress the immune system. These include danazol (an androgen) or fibrate and nicotinic acid (both blood lipids). There is a particular risk of co-administration of statins such as atorvastatin with cyclosporine. It can lead to severe cases of muscle rhabdomyolysis. If the simultaneous administration of the active ingredients is unavoidable, the statins must be dosed weaker by the doctor.
Acid-binding agents or colestipol (fat-sinking anion exchange resin) reduce blood atorvastatin levels by 35 percent. These drugs should therefore be taken one hour before atorvastatin.
Substances that are broken down in the body by the same enzyme system (cytochrome CYP3A4) as atorvastatin result in increased levels of atorvastatin. These drugs include imatinib, antifungals such as itraconazole, erythromycin and clarithromycin (both macrolide antibiotics), HIV-1 protease inhibitors and grapefruit juice.
Concurrent use of the drug with the “pill” increases blood levels of the hormones norethisterone and ethinylestradiol.
Atorvastatin also interacts with fusidic acid (antibiotic), amiodarone (for cardiac arrhythmias), verapamil-like drugs (for angina pectoris), and bosentan (for pulmonary hypertension).