Aspirin side effects

Manufacturer: Bayer Vital GmbH – Active ingredient: acetylsalicylic acid

dosage form: tablet

prescription

side effects

A. Low doses (100 and 300 milligrams) – Common side effects:
Gastrointestinal discomfort such as heartburn, nausea and vomiting, abdominal pain, diarrhea, minor blood loss from the gastrointestinal tract (microbleeds).

Occasional side effects:
Gastrointestinal bleeding, iron deficiency anemia (after prolonged use), gastrointestinal ulcers, hypersensitivity reactions, allergic skin reactions.

Rare side effects:
gastrointestinal breakthrough, severe skin reactions (including erythema exsudativum multiforme), drop in blood pressure, dyspnea seizures, shock, Quincke’s edema, severe bleeding (for example in the brain).

Very rare side effects:
Liver enzyme elevation, renal dysfunction, low blood sugar.

Side effects without frequency:
headache, dizziness, confusion, hearing impairment, tinnitus, nosebleeds, bleeding gums, skin bleeding, bleeding time extension.

B. High doses (from 500 milligrams)
Common side effects:
Gastrointestinal discomfort such as heartburn, nausea and vomiting, abdominal pain.

Occasional Side Effects:
Allergic Skin Reactions.

Rare side effects:
Gastrointestinal bleeding, peptic ulcer, severe bleeding (eg, brain hemorrhage), severe cutaneous reaction (including erythema exudative multiforme), drop in blood pressure, dyspnoea, shock, Quincke’s edema .

Very rare side effects:
iron deficiency anemia, gastrointestinal breakthroughs, liver enzyme enhancement,

Side effects without frequency:
headache, dizziness, hearing, ringing, confusion, nosebleeds, bleeding gums, skin bleeding, bleeding time extension.

Special features:
In gout patients, a gout attack can be triggered even by a low drug dosage.

If black stools or bloody vomiting (signs of severe gastric bleeding) occur, notify the doctor immediately.

Long-term intake of acetylsalicylic acid may cause headaches which may lead to relapse and headaches.

Long-term use, especially with combinations of several analgesic drugs, can lead to permanent kidney damage with the risk of kidney failure (called analgesic nephropathy).

interactions

The simultaneous intake of acetylsalicylic acid alters the action of the following active substances and groups of active ingredients:

  • Anticoagulants (anticoagulants) have a stronger effect, causing severe bleeding. Particularly dangerous are combinations with clopidogrel and vitamin K antagonists (warfarin, dicoumarol).
  • Digoxin, lithium or barbiturates are increased in their concentration in the blood, increasing the risk of intoxication.
  • Sulfonylureas are potentiated in action, which can lead to hypoglycaemia.
  • Methotrexate (cytotoxin for the treatment of rheumatism and cancer), the thyroid hormone triiodothyronine or sulfonamides are potentiated in effects and side effects.
  • all non-steroidal anti-inflammatory drugs are potentiated in action and side effects.
  • The concentration of the antiepileptic drug valproic acid in the blood is increased, which increases the effect and side effects.
  • Dehydrating agents such as loop diuretics, spironolactone and canrenoate, hypotensives and gout remedies are reduced in their action.
  • with glucocorticoids and alcohol increases the risk of gastrointestinal bleeding.

Notes: Acid-binding agents (antacids) increase the secretion of acetylsalicylic acid, which may affect its efficacy.

The concomitant use of acetylsalicylic acid for blood thinning with ibuprofen must be avoided at all costs. Ibuprofen partially abolishes the blood-thinning effect of acetylsalicylic acid. Instead of ibuprofen, diclofenac, which does not show this interaction, can be used if necessary.

Potential Aspirin side effects may include: