Arcoxia contraindications and warnings


Following is information on contraindications to the use of etoricoxib in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Etoricoxib not be used?

The active substance should not be used at:

  • Hypersensitivity to etoricoxib
  • Acid-induced gastric ulcers or bleeding from the stomach or intestine
  • Patients who responded to the use of acetylsalicylic acid or non-steroidal anti-inflammatory drugs (NSAIDs), including COX-2 (cyclooxygenase 2) inhibitors, with bronchospasm, allergic rhinitis, nasal swelling, facial swelling, hives or other allergic-type reactions
  • severe hepatic impairment (albumin concentration in the blood below 25 grams / liter or Child Pugh above or equal to 10)
  • Renal impairment with estimated creatinine clearance below 30 milliliters / minute
  • chronic inflammatory bowel disease
  • Heart failure (NYHA Class II to IV)
  • Patients with a high blood pressure that persistently exceeds 140/90 mmHg and has not been adequately treated
  • Physician-identified coronary heart disease (angina)
  • Circulatory disorders in the arms and legs (“intermittent claudication”) and / or circulatory disorders of the brain.

Etoricoxib may only be used at

    after a benefit / risk assessment by the physician and under his control

  • elderly patients, concomitant use of other NSAIDs or acetylsalicylic acid or gastric or previous history of gastrointestinal bleeding, because these are associated with an increased risk of complications in the digestive tract
  • significant risk factors for the occurrence of cardiovascular complications such as high blood pressure, lipid metabolism disorders, diabetes and smoking, because the use of the drug increases the risk
  • Significantly impaired kidney function, discomfort from cardiac insufficiency already at rest or cirrhosis of the liver, as they exacerbate the risk of renal dysfunction.
  • Patients with heart failure, dysfunction of the left ventricle, high blood pressure and fluid retention (edema), because etoricoxib may exacerbate it
  • dehydration; this must first be fixed.

What should you watch out for during pregnancy and lactation?

As with other agents known to inhibit the enzyme COX-2, the use of etoricoxib is not recommended for women trying to get pregnant.

Etoricoxib has not been used to treat pregnant women so the risk to both mother and baby can not be estimated. However animal studies have shown harmful effects. The potential risk to humans during pregnancy is unknown. Etoricoxib, like other agents that inhibit the body’s production of prostaglandins (tissue hormones), can lead to labor weakness during the last trimester of pregnancy and premature closure of the blood supply to the child (ductus botalli). The use of etoricoxib in pregnancy is therefore not allowed. If a woman becomes pregnant during therapy, the drug must be discontinued.

It is not known if etoricoxib is excreted in human milk while it is detected in suckling rats. Women who take etoricoxib should not breast-feed.

What should be considered in children?

Children and adolescents under the age of 16 should not be treated with etoricoxib.

Warnings and Precautions

  • At the first sign or symptoms of liver dysfunction (nausea, fatigue) a doctor should be consulted.
  • At the first sign of skin or mucous membrane reactions and allergic symptoms, treatment with the drug should be stopped immediately.
  • Fever or other signs of inflammation or infection may be obscured by the drug.
  • The medication may cause dizziness, dizziness or drowsiness, making driving a car or operating machinery dangerous.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.