What side effects can Etoricoxib have?
Below you will find the most important information about possible known side effects of etoricoxib.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
Fluid retention (edema), dizziness, headache, palpitations, high blood pressure, abdominal discomfort (stomach ache, flatulence, heartburn), diarrhea, digestive disorders, abdominal discomfort, nausea, elevation of liver function (ALAT and ASAT), blotchy skin bleeding, weakness, fatigue, flu-like illness.
Occasional side effects:
gastrointestinal inflammation, upper respiratory tract infection, urinary tract infections, anemia (predominantly from gastrointestinal bleeding), blood count changes (white blood cell and platelet deficiency), changes in appetite, weight gain, anxiety, depression , Impaired concentration, taste disorders, insomnia, nervous hyperplasia or insensitivity, blurred vision, conjunctivitis, tinnitus, dizziness, atrial fibrillation, myocardial insufficiency, nonspecific ECG changes, angina pectoris, myocardial infarction, flushing, stroke, transient circulatory disorder in the brain, coughing, dyspnea , Nosebleeds, abdominal distension, gastric reflux, disorders of bowel movement, constipation, dry mouth, peptic ulcer, irritable bowel syndrome, esophagitis, oral mucosal ulcers, vomiting, gastritis, facial swelling, itching, rash, muscle spasms, Muscle pain, bone pain, muscle stiffness, protein in the urine, increase in creatinine in the blood, pain in the chest, increase of urea nitrogen in the blood, increase in creatine kinase in the blood, excess of potassium in the blood, increased uric acid content of the blood / p>
Rare side effects:
redness, sodium deficiency in the blood.
Very rare side effects:
Hypersensitivity reactions including blood vessel swelling, allergic reactions including shock, confusion, delusions, hypertensive crisis, bronchospasm, acid gastric ulcers including gastrointestinal bleeding and bleeding (especially in elderly patients), hepatitis, hives, severe Skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), renal impairment including renal failure.
Side effects of unknown frequency:
restlessness, palpitations, cardiac arrhythmia, pancreatitis, jaundice.
The following serious side effects were observed with the use of non-steroidal anti-inflammatory drugs and can not be ruled out for etoricoxib: renal toxicity to renal inflammation (interstitial nephritis) and renal impairment (nephrotic syndrome); Liver damage including liver failure.
Because etoricoxib increases the risks of heart attack and stroke with dose and duration of treatment, the physician will use the shortest possible treatment duration and the lowest effective daily dose. Therefore, the need for therapy and its success, especially in osteoarthritis patients, will be reviewed at regular intervals.
In case of abnormal liver function, the doctor must check the further course. At the first sign or symptoms of liver dysfunction or prolonged elevation of liver function (three times the upper limit of normal), the physician should discontinue therapy with etoricoxib.
At the first sign of rash, mucosal damage or other signs of hypersensitivity, etoricoxib should be discontinued immediately.
Etoricoxib may obscure fever or other symptoms of inflammation or infection.
What interactions does etoricoxib show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Patients treated with warfarin for hemodilution will be boosted by etoricoxib. In order to prevent bleeding, coagulation must often be monitored by a doctor, especially in the first few days after initiation of therapy or after dose changes of etoricoxib.
Etoricoxib can reduce the effects of dehydrating and hypotensive agents from the ACE inhibitor and AT1 receptor groups. Reduce antagonists. This increases the risk of further deterioration of renal function and acute renal failure, which may be transient. Therefore, the doctor will prescribe such a combination especially in elderly patients with caution.
Concomitant use of etoricoxib with acetylsalicylic acid in pain-relieving doses (300 to 500 milligrams) or with other non-steroidal anti-inflammatory drugs is not recommended since They lead to serious side effects in the stomach and intestines. Acetylsalicylic acid for heart protection (50 to 100 milligrams daily) can be combined with etoricoxib, although more stomach and intestinal problems can occur.
The immunologic agents ciclosporin and tacrolimus are kidney-damaging. This side effect may also be enhanced by etoricoxib, as with other non-steroidal anti-inflammatory drugs.
Etoricoxib increases the concentration of some drugs in the body and thus their risk of side effects. That’s the case with
- Lithium, which is used as an antidepressant
- Methotrexate (for rheumatism and cancer), whose toxicity is increasing
- Estrogen-progestin combinations for contraception (“pill”) and estrogen-progestagen combinations for menopausal symptoms that increase the risk of blood vessel blockage
- the cardiac glycoside digoxin, therefore, especially high-risk patients must be carefully monitored by the doctor
- Salbutamol for use (against asthma) and the hypotensive drug Minoxidil because etoricoxib inhibits their degradation in the body.
Etoricoxib itself is only metabolized by the tuberculosis agent rifampicin, which weakens its action.