What side effects can clomipramine have?
Below you will find the most important information about possible known side effects of clomipramine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
dry mouth, nasal congestion, constipation, dizziness, dizziness, increased sweating, hot flashes; Disorders of accommodation (problems to focus on the eyes), speech disorders, tremors, hypotension with circulatory problems and tachycardia, weight gain, liver enzyme increase in value (temporarily).
Common side effects:
problems with urination (bladder weakness), thirst, diarrhea, nausea and vomiting to anorexia, hypersensitivity reactions such as skin allergies and rashes (urticaria, rash), inner restlessness, fatigue, sleep disorders, mood swings, Increased anxiety, agitation, headache, numbness and tingling, as well as sexual dysfunction (feeling of pleasure and potency), cardiac arrhythmias such as arrhythmias, conduction disturbances or palpitations.
Rare side effects:
confusion states, dysregulations, orientation disorders. Liver dysfunction, bowel obstruction, urinary retention, collapse conditions, Schwartz-Bartler syndrome, blood sugar level elevations or blood sugar level reductions, weight loss, milky mammary gland secretions or male mammary gland enlargement (gynecomastia).
Very rare side effects:
aggression behavior, motor disorders such as akathisias and dyskinesias, EEG changes, muscle twitching (myoclonus), weakness, impaired locomotor coordination and balance regulation (ataxia), musculoskeletal disorders or neurological pain (polyneuropathy), speech disorders, Fever, dilation of the pupil (mydriasis), conduction disturbances and reinforcements of existing myocardial insufficiency, increase in blood pressure, abdominal pain, fainting, stomatitis, tongue inflammation (glossitis), jaundice (hepatitis) also in connection with yellowing of the skin, allergic skin reactions such as itching, skin bleeding, Photosensitivity with symptoms such as dizziness, eye flutter and headache; Ulcers, hair loss, circulatory disorders such as tinnitus, circulatory disorders, glaucoma, glaucoma, blood cell changes such as leukopenia or agranulocytosis, allergic lung reactions (eosinophilia).
Many of the unwanted side effects are most pronounced at the beginning of treatment and usually lessen as the body gets used to the drug.
Special risk groups such as epileptics, alcoholics or patients taking other psychotropic medications may experience seizures of the central nervous system.
In elderly or brain-damaged patients, the drug may induce delirium. Confusion states and other delirious symptoms such as disorientation or hallucinations are common, especially in the elderly and patients with Parkinson’s disease or Parkinson’s syndrome.
Acute overdose is characterized by over-excitability (including convulsions), impaired consciousness (even coma), cardiac arrhythmia and respiratory arrest. If you see signs of these symptoms, but also increased dry mouth or urinary problems and increased heart rate, this indicates a beginning of overdose. Talk to her doctor immediately
If clomipramine is injected into the blood stream, local reactions or a so-called anaphylactic shock (hypersensitivity reaction) may occur in individual cases.
Treatment with clomipramine should not be stopped abruptly as it may cause side effects such as nausea, insomnia and anxiety. It is recommended to reduce the dose slowly (to escape).
The widespread use of the drug has shown that ingestion may increase the risk of fractures.
What interactions does clomipramine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Interactions of clomipramine consist mainly of drugs that also have a dampening effect on brain activity such as sedatives and hypnotics, Tranquillizer or neuroleptics. With these remedies, but also with alcohol consumption, clomipramine can lead to a mutual reinforcement of the tireding (sedating) effect. Neuroleptics also enhance the antidepressant action of clomipramine.
Agents that have an anticholinergic effect, such as clomipramine, also mutually reinforce each other. These include, for example, phenothiazines (a group of psychotropic drugs), antiparkinsonian drugs such as biperiden, antihistamines (used as sleeping pills and against allergies) or atropine (for example, contained in eye drops).
Cimetidine (for gastric ulcers) and Methylphenidat (used for example in hyperactive children) increase the effects and side effects of the active ingredient clomipramine.
Catecholamines, even though they occur as a vasoconstrictor in local anesthetics, are potentiated by clomipramine in their action on the nervous system.
Special medical attention is needed if, prior to or concurrent with clomipramine, antidepressants from other classes of agents have been or are being taken. This applies in particular to the active substances fluoxetine and fluvoxamine, but also to other tricyclic antidepressants. Clomipramine co-administration enhances the effect and increase the frequency of side effects. The dose of Clomipramine and / or the other antidepressants to be taken must therefore be adjusted by the doctor.
Antidepressants from the group of MAO inhibitors must not be taken together with clomipramine because of serious side effects. MAO inhibitors must be discontinued at least 14 days before clomipramine. Even with a reverse change from clomipramine to MAO inhibitors, this minimum interval of 14 days applies.
Neuroleptics, which also affect the psyche, enhance clomipramine in its action. This also applies to concomitant treatment with anticonvulsants such as benzodiazepines or barbiturates. Increased seizures of the central nervous system can occur here.
Clomipramine may reduce or eliminate the effects of some antihypertensive drugs such as guanethidine, reserpine, betanidine, clonidine or alpha-methyldopa.
Special care should be taken with concomitant administration of thyroid hormones, as unwanted cardiac-damaging effects can be exacerbated.
Anti-arrhythmic agents of the quinidine or amiodarone type are potentiated by clomipramine.
Agents that accelerate the breakdown of clomipramine in the liver, such as barbiturates, the epilepsy agents carbamazepine and phenytoin, nicotine or hormonal Contraceptives, reduce the effects of clomipramine. Carbamazepine and phenytoin are simultaneously enhanced in their action by clomipramine.
Co-administration of coumarin-type coagulants such as phenprocoumon may result in changes in blood coagulation. The coagulation values must therefore be checked regularly by a doctor.