Amoxicillin side effects

What side effects can Amoxicillin have?

Below you will find the most important information about possible, known side effects of Amoxicillin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Very common side effects:
rashes (in patients with concurrent viral infection); Stomach depressions, nausea and vomiting, loss of appetite, flatulence, loose stools, diarrhea.

Common side effects:
Hypersensitivity reactions (in the form of rashes, itching, fever), mucosal inflammations (especially in the mouth), dry mouth, impaired taste.

Uncommon side effects:
Changes in the blood count, anemia, transient hepatic dysfunction, elevation of certain liver enzymes in the blood, hypersensitivity reactions (in the form of vasculitis and tissue swelling due to leakage from blood vessels), laryngeal swelling with dyspnea, renal inflammation due to the deposition of immune complexes .

Rare side effects:
Severe allergic reactions (in the form of extensive, severe skin symptoms such as formation of reddish skin nodules), fluid retention in the tissue (edema), dandruff addiction with dehiscence and loss of hair and fingernails, formation of a black hairy tongue > when given into the vein:
Pain at the injection site.

isolated cases:
Significant changes in the blood count (strong lack of white blood cells and platelets), blood clotting disorders.

Special features:
A penicillin allergy (hypersensitivity) usually shows up as a sudden urticaria. It can also lead to a shock reaction with a sharp drop in blood pressure or severe respiratory distress. In both cases the therapy should be stopped immediately.

Especially in children, the use of the drug may cause tooth discoloration, so good oral hygiene is important.

If severe, persistent diarrhea occurs during or after therapy, pestilence induced by antibiotics (pseudomembranous colitis) may be the cause. Therapy must be stopped immediately and diarrhea must be medically treated with vancomycin.

Prolonged or repeated administration may result in additional infections with amoxicillin-insensitive bacteria or with yeasts.

What interactions does amoxicillin show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Other antibiotics that inhibit the growth of bacteria (bacteriostatic effect) should not be combined with amoxicillin because the substances interfere with each other in their effectiveness. These include, for example, tetracyclines and erythromycin.

Co-administration of anti-inflammatories such as phenylbutazone and indomethacin, diuretics or gout agents such as probenecid or allopurinol potentiates the effects and side effects of amoxicillin.

Amoxicillin therapy may increase the effects of cardiac glycosides and blood thinners (anticoagulants) such as phenprocoumon.

Vaccination with live vaccines may be ineffective.

The active substance may reduce the intake of hormonal contraceptives (pill) from the intestine and thus impair its effectiveness. Therefore, additional, non-hormonal contraception is necessary.

Some laboratory tests, such as measuring sugar or urobilinogen from the urine, may show false results.

Potential Amoxicillin side effects may include: