About Amitriptyline

3.5 rating based on 114 ratings
Rating: 3.3 Reviews: 114
About Amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of its calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

What is the purpose of this ingredient?

  • treat depression
  • mild to moderately severe as well as severe to very severe chronic pain as part of a treatment plan such as relieve migraine headaches or fibromyalgia
  • Release fear
  • Reduce nervousness
  • Alleviate Sleep Disorders

This is how Amitriptyline works

Below you will learn more about the fields of application and the mode of action of amitriptyline.
Please also read the information on the drug classes tri- and tetracyclic antidepressants, antidepressants, to which the active ingredient amitriptyline belongs.

Areas of application of the active ingredient amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of the calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

The active ingredient can also be used for chronic pain, which often has a mental component, within a therapeutic concept. The pain scale that covers amitriptyline ranges from mild to moderately severe pain to severe to very severe pain. For example, headache in migraine attacks and fibromyalgia (musculoskeletal pain) can be treated with amitriptyline.

For the following application areas of Amitriptyline , in-depth information is available:

  • depression
  • Pain (strong to very strong)
  • anxiety disorders

Action of Amitriptyline

Amitriptyline belongs to the active ingredient group of tricyclic antidepressants and also has its mode of action.

All brain nerve reactions are mediated by messengers such as serotonin and norepinephrine. These messenger substances are stored in small vesicles at the nerve endings and are released on excitement of the nerve. In this way they reach other nerves and bind to special binding sites (receptors). The affected nerves then transmit the stimulus signal. Once they have fulfilled their task, the messenger substances are returned to their storage via special transport systems or degraded by enzymes.

Amitriptyline has a dual effect. Once the active ingredient in the brain occupies different binding sites for messenger substances and thus changes the influence of these messengers on the brain metabolism. Secondly, amitriptyline blocks transport substances that return the messengers serotonin and norepinephrine to their storage sites after signal transmission. As a result, serotonin and norepinephrine remain longer at the site of action and their effectiveness increases. Amitriptyline in this way triggers anxiety and tension states and reverses depressive moods. The soothing effect of amitriptyline usually occurs very quickly, while the mood-improving effect begins after about two weeks of regular use.

Chronic pain often interferes with the processing of pain signals in the brain. The messenger serotonin plays a major role in building a filter for incoming pain signals. By influencing serotonin, amitriptyline can replace the constant use of painkillers. The active ingredient must be taken for pain relief but then regularly over a long period of time.

Potential Amitriptyline side effects may include:

Amitriptyline used to treat the following diseases:

  1. Judy P. Livingston says:
    3.5 rating

    Amitriptyline for Depression

    I had a major depressive episode today and would almost say Amitryptiline saved my life. I tried many antidepressants, but amitryptiline was the only one that helped me out of the severe depression. I had no side effects.

    Side effects: No side effects
  2. Ollie D. Riley says:
    3.0 rating

    Amitriptyline for High blood pressure; Depression

    I could not do anything with Amitryptiline, it did not work! Trevilor 150 I can only highly recommend, with these tablets, I’m fine. Ramipril has hit very well and quickly for my hypertension.

    Side effects: No side effects
  3. John A. Keegan says:
    3.0 rating

    Despite the drug combination, I still have a lot of pain, I hope that my doctor and I can find a combination of medicines that will take my pain away. Maybe one of them has some experience with medications and pain and can help me to get rid of the pain (without surgery). I have not had any side effects yet and hope that it stays that way.

    Side effects: No side effects
  4. Andrea T. Mosley says:
    4.0 rating

    Amitriptyline for Pain (chronic)

    confused, unfocused, unbelievable nausea with dizziness, trembling, dejected, completely out of the lot. Relatively good pain relief, but under these side effects no quality of life. Immediately discontinued without consultation with the doctor.

  5. Susan M. Molina says:
    2.5 rating

    Since 2002 I have a massive intolerance to all medicines, also homeopathic kind and also vitamin tablets. As soon as I take them for more than 3-4 days, I get a strong feeling of muscle weakness in the legs, severe pain in the shoulder, a headache, dizziness, sweats, high pulse. I feel very ill then. I would, however, urgently need to take pills. I have heart pills, hip problems, osteoporosis and severe nervous disorders. I was with all doctors, naturopaths etc. Who has these problems too and can help me. Best regards Monika

    Side effects: Sweats; Headache; Dizziness
  6. Andrew T. Smith says:
    3.5 rating

    Amitriptyline for Depression

    Dry mouth, sweating, encapsulation of the environment, forgetfulness A few days ago, I disputed with the prescribing painkiller, and now do not know where the next recipe should come from? Have already tried 2 withdrawals. But then the phantom pains get very strong and I’ll go crazy soon! Who can help me as soon as possible ??? Information to bbruch@online.de Bruch B.

    Side effects: Sweat; Mouth dryness
  7. Denise S. Yelverton says:
    2.5 rating

    Amitriptyline for Depression

    Weight gain about 6 kg, extreme dry mouth, suicide attempt in the period of a day clinic visit.

  8. Cheryl D. Thomas says:
    4.0 rating

    Amitriptyline for Migraine; Pain (acute); Depression

    After the start of taking Topamax it came pretty quickly to the described weight loss – pleasant – but also to disorientation. Can also be related to previous brain surgery. For the treatment of focal epilepsy and migraine, I can only recommend Topamax. Since SAB with Clip Brain Aneurysm, I have depression that is getting stronger and now being treated with amitriptyline. Now, my brain sometimes runs like a DVD player in fast-forward or I fall asleep at the desk, can no longer assign things, I’m just completely confused. 1 and 2 do not seem to be compatible?

    Side effects: Dizziness; Fatigue
  9. Lillie R. Brice says:
    4.0 rating

    Amitriptyline for Pain (chronic)

    After two days of taking a funny rash (hives), which affected the whole body. After taking allergy tablets, it got better, but the skin is still very, very dry and irritated. Took it only very briefly therefore the following symptoms may not be representative? Tired, weak, constant hunger.

    Side effects: Appetite increase; Fatigue