About Amitriptyline

3.5 rating based on 114 ratings
Rating: 3.3 Reviews: 114
About Amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of its calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

What is the purpose of this ingredient?

  • treat depression
  • mild to moderately severe as well as severe to very severe chronic pain as part of a treatment plan such as relieve migraine headaches or fibromyalgia
  • Release fear
  • Reduce nervousness
  • Alleviate Sleep Disorders

This is how Amitriptyline works

Below you will learn more about the fields of application and the mode of action of amitriptyline.
Please also read the information on the drug classes tri- and tetracyclic antidepressants, antidepressants, to which the active ingredient amitriptyline belongs.

Areas of application of the active ingredient amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of the calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

The active ingredient can also be used for chronic pain, which often has a mental component, within a therapeutic concept. The pain scale that covers amitriptyline ranges from mild to moderately severe pain to severe to very severe pain. For example, headache in migraine attacks and fibromyalgia (musculoskeletal pain) can be treated with amitriptyline.

For the following application areas of Amitriptyline , in-depth information is available:

  • depression
  • Pain (strong to very strong)
  • anxiety disorders

Action of Amitriptyline

Amitriptyline belongs to the active ingredient group of tricyclic antidepressants and also has its mode of action.

All brain nerve reactions are mediated by messengers such as serotonin and norepinephrine. These messenger substances are stored in small vesicles at the nerve endings and are released on excitement of the nerve. In this way they reach other nerves and bind to special binding sites (receptors). The affected nerves then transmit the stimulus signal. Once they have fulfilled their task, the messenger substances are returned to their storage via special transport systems or degraded by enzymes.

Amitriptyline has a dual effect. Once the active ingredient in the brain occupies different binding sites for messenger substances and thus changes the influence of these messengers on the brain metabolism. Secondly, amitriptyline blocks transport substances that return the messengers serotonin and norepinephrine to their storage sites after signal transmission. As a result, serotonin and norepinephrine remain longer at the site of action and their effectiveness increases. Amitriptyline in this way triggers anxiety and tension states and reverses depressive moods. The soothing effect of amitriptyline usually occurs very quickly, while the mood-improving effect begins after about two weeks of regular use.

Chronic pain often interferes with the processing of pain signals in the brain. The messenger serotonin plays a major role in building a filter for incoming pain signals. By influencing serotonin, amitriptyline can replace the constant use of painkillers. The active ingredient must be taken for pain relief but then regularly over a long period of time.

Potential Amitriptyline side effects may include:

Amitriptyline used to treat the following diseases:

  1. Alice B. Davis says:
    3.5 rating

    For almost 8 years I have had severe stomach pains and nausea almost daily (especially in the morning). Now I take this medication for 2 months and it has improved a lot. I’ll take it even longer, but I’m surprised it (unlike all other things) has already made an improvement. I think I tolerate it well, although from time to time dizziness occurs, my nose is often clogged and I have gained some weight (which may also be because I finally enjoy the food again).

  2. Oscar N. Banuelos says:
    3.5 rating

    Amitriptyline for Muscle tenseness

    sifrol 0018 mg only partially help, I still often have the tingling and those restless legs, walk around at night and have to move. Totally killed in the daytime, I wake up in the morning and am not able to do anything or concentrate until lunchtime. I realized that if I go a lot during the day then the night is over.

  3. Charlene M. Young says:
    4.0 rating

    Amitriptyline for Sleep disorders

    Due to a significant, chronic sleep disorder, I have o. g. Drug prescribed and taken for about 2 years, regularly, taken. Overall, the effectiveness is good for me, and I have developed no tolerance for this drug, I always take always consistent dose. However, that certainly depends on discipline and consistency. As far as the side effects are concerned, I have already seen a whole series, in particular the weight gain (15 kg / 2 years), which in any case depends on the medication intake. Long-term changes in diet, etc. are very difficult, because on the one hand, I was more hungry and on the other hand, even with changes in diet and physical activity very difficult to no weight loss. In addition, there is still a reduced performance and concentration capacity during the day, but not serious for me, but already noticeable. Then, of course, the risk of dependency, as with so many antidepressants and benzodiazepines. Also, I’m usually pretty tired after getting up in the morning, but that basically comes with me during the day.

  4. Margaret C. Bessler says:
    4.5 rating

    I take the med. For about 1 year, after a phase of about 3 weeks, it also began to work well against the anxiety disorders. As unpleasant side effects, about 1 week. after receipt of income, came first an absolute orgasm disorder, I was, despite the desire not able to somehow come to orgasm, which I always succeeded without problems several times in succession. Gradually, it turned out to be an absolute loss of libido – perhaps because of frustration of not being able to come. Today, I have no physical desire for sex, but mentally. Since an absolute vaginal dryness associated with it, I have no traffic with my husband for about 11 months, which charged me, but much more burden him. Nevertheless, my therapist advised me to continue taking the medication during the therapy, ie for about 6 months, because it works and you can live without or with a different kind of sex. And let’s be my early need to have sex every day, also not normal. It also gives me hope that my sexuality will return to normal relatively soon after the medication is discontinued.

    Side effects: Orgasm disorder; Libido loss
  5. Floyd J. King says:
    2.0 rating

    Amitriptyline for Depression

    Strong heartburn. Extremely unpleasant. Otherwise good drug.

    Side effects: Heartburn
  6. Ted J. Butler says:
    4.5 rating

    Amitriptyline for A headache

    Hello, I have been taking amitriptyline for 3 months now. Side effects: – Dry mouth – Fatigue throughout the day – Slight weakness (when you leave after a few hours) – Strong appetite – Heartburn Despite these side effects, I can only recommend the drug. It helped a lot to get rid of my winter depression. Despite the very strong appetite and greatly increased food, no weight gain is observed. It may also be due to my sport (triathlon), but the other side effects are negligible. Have / had tension headaches, but have completely gone after taking the drug for 2 weeks hab.

  7. Rachel J. Vaughn says:
    2.5 rating

    Amitriptyline for Sleep disorders

    I am taking 10mg for strong and permanent sleep and sleep disorders since 4 weeks. I have hardly any side effects, at most a little more thirsty at night and sometimes a bit tired during the day. But compared to before (2-4h sleep a night, not in one piece) the fatigue is laughable. I have not gained any weight at all, but I have always been relatively healthy and have been doing endurance sprays regularly for years, at 60-90 minutes 2-3 times a week at the stress limit.

    Side effects: Daytime tiredness; Thirst
  8. Randy N. Nicholson says:
    4.5 rating

    Amitriptyline for Depression

    Amitriptyline was prescribed for suspected depression. When I took the drug for the first few weeks, I did not notice any effect, but instead it blew me completely a few hours after taking it. It is therefore advisable to take the drug initially only in the evening, so that one sleeps, while the side effects would occur. My doctor recommended that I take a tablet early after 3 weeks. Since I’m suffering from chronic fatigue anyway, I let that be after a few tries as it increased my fatigue. Nevertheless, it came to a slight mood-enhancing effect and made me with evening intake not the next day tired. The sedating side effect decreased quite abruptly. After a few weeks, no side effects were noticeable.

    Side effects: Daytime tiredness; Fatigue
  9. Charles L. Torres says:
    3.5 rating

    Amitriptyline for Depression

    sleep-inducing, pain-relieving with back problems, in drop form unacceptable mouth deafness and cruel taste, as tablets ok, weight gain, tapering the drug takes patience and time

  10. Mark L. Gonzalez says:
    4.5 rating

    I was prescribed amitriptyline because of severe vulvar pain and only took about three weeks because of itching. It must be said that I am allergic and neurodermatitis. It has itchy, especially the body parts that have ever been affected by atopic dermatitis (actually, but not for a long time). The explanation for the itching, which immediately became better after the discontinuation of the drug, probably lies in the liberation of histamines, which have increased my probably already high levels of histamine even more. Ami is not combinable well with antihistamines (contraindication) and therefore unsuitable for me in the long run. Other side effects included morning tiredness, diarrhea and numbness in the arms.

  11. Christopher P. Kirk says:
    3.0 rating

    Amitriptyline for Depression

    The medication blushes away .. Although I only take 25 MG .. I am broken .. Muscle hurt .. Headache … Tired all day … Powerless … Used … I would recommend it to anyone

    Side effects: Confusion; Headache; Fatigue
  12. Linda S. Kinsella says:
    2.0 rating

    Amitriptyline for Fibromyalgia

    I’ve been taking amitriptyline (antidepressants) for 8 months, which is used to relieve pain in my illness. For several weeks now, I have been breathing pauses at night, suddenly wake up, open my eyes and gasp like a fish.

  13. Daniel S. Reed says:
    3.5 rating

    Amitriptyline for Morbus sudeck

    Amitriptyline was given to me as part of the treatment of Sudeck’s disease in combination with Arcoxia and Calcitonin. This adds to the already daily intake of Beloc Zok, SimvaHexal and Nexium mups. At intervals of about 2 hours in the evening, I took one tab each, for a total of 2 tablets before going to bed and woke up at night with severe heart problems and an extreme feeling of pressure in the torax area, had shortness of breath and felt extremely bad. The complaints were so severe that I was about to call an ambulance. The next morning, I consulted with my attending physician because I did not know which of the medications triggered the symptoms. The doctor typed amitriptyline, which I then discontinued immediately. The complaints did not occur then.

    Side effects: Difficulty in breathing
  14. Susan K. McDaniel says:
    4.0 rating

    Amitriptyline for Sleep disorders

    I take a 25 mg prolonged-release amitriptyline in the evening. The first four weeks I slept a lot, in the first week 18 hours a day. But after four weeks, I had a normal need for sleep again. I take amitriptyline for recurrent chronic headaches. It reduces the number of pain days, but does not eliminate the headache problem. In addition, I take it against sleep disorders. During the first 3 months, it had a sleep-inducing effect, but then no more.

  15. Hillary R. Gillespie says:
    4.0 rating

    Amitriptyline for Sleep disorders; Depression

    I took the drug for 6 years, I should take it in the evening before going to sleep, so that I can sleep … I still could not sleep in and certainly not … But my doctor was convinced of the drug and there Familiar with a doctor, I took it … I could have taken valerian, would have probably come out the same … The side effects have been mainly weight gain, morning sluggishness and inner restlessness throughout the day heard … One Half a year after I started doing it, I gained 10kg … Due to the sluggishness, I could not follow my studies anymore and finally had to quit … I would never take it again and advise against it ….

  16. Heather J. Peterman says:
    4.5 rating

    Amitriptyline for Depression

    Because of a restless depression I got mirtazepin, 2mg 15mg after that 30mg. They get very tired very quickly, then I got the side effect of restless legs. Unfortunately the tablets strengthened my depression, I was very irritable, at times aggressive. They were deposed and me got amitriptilin 2x25mg. The fatigue is noticeable about one hour after the intake, dizziness when getting up and slight hangover the next day. On the 5th day of intake I got tachycardia, at rest around 120 / min and after exercise the pulse went up to 145 !!! ECG was inconspicuous, my psychiatrist then halved the dose. From today I take only 12.5 mg for 5 days, then slowly increase the dose. But I think that these are the right tablets for me. I am doing better despite the tachycardia!

  17. Sergio L. Garver says:
    3.0 rating

    Amitriptyline for Sleep disorders

    I got them for insomnia and only take one tablet every few weeks. Most of the time I really sleep really deep. The disadvantage is only I have early problems to wake up. Although I’ll take her soon evening

    Side effects: Hangover
  18. Ann M. Selby says:
    2.5 rating

    Amitriptyline for Pain (chronic)

    At the beginning of the therapy fatigue, problems with the eyes. After about 4 months weight gain, constant fullness, feeling of water retention, joint pain