About Amitriptyline

3.5 rating based on 113 ratings
Rating: 3.3 Reviews: 113
About Amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of its calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

What is the purpose of this ingredient?

  • treat depression
  • mild to moderately severe as well as severe to very severe chronic pain as part of a treatment plan such as relieve migraine headaches or fibromyalgia
  • Release fear
  • Reduce nervousness
  • Alleviate Sleep Disorders

This is how Amitriptyline works

Below you will learn more about the fields of application and the mode of action of amitriptyline.
Please also read the information on the drug classes tri- and tetracyclic antidepressants, antidepressants, to which the active ingredient amitriptyline belongs.

Areas of application of the active ingredient amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of the calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

The active ingredient can also be used for chronic pain, which often has a mental component, within a therapeutic concept. The pain scale that covers amitriptyline ranges from mild to moderately severe pain to severe to very severe pain. For example, headache in migraine attacks and fibromyalgia (musculoskeletal pain) can be treated with amitriptyline.

For the following application areas of Amitriptyline , in-depth information is available:

  • depression
  • Pain (strong to very strong)
  • anxiety disorders

Action of Amitriptyline

Amitriptyline belongs to the active ingredient group of tricyclic antidepressants and also has its mode of action.

All brain nerve reactions are mediated by messengers such as serotonin and norepinephrine. These messenger substances are stored in small vesicles at the nerve endings and are released on excitement of the nerve. In this way they reach other nerves and bind to special binding sites (receptors). The affected nerves then transmit the stimulus signal. Once they have fulfilled their task, the messenger substances are returned to their storage via special transport systems or degraded by enzymes.

Amitriptyline has a dual effect. Once the active ingredient in the brain occupies different binding sites for messenger substances and thus changes the influence of these messengers on the brain metabolism. Secondly, amitriptyline blocks transport substances that return the messengers serotonin and norepinephrine to their storage sites after signal transmission. As a result, serotonin and norepinephrine remain longer at the site of action and their effectiveness increases. Amitriptyline in this way triggers anxiety and tension states and reverses depressive moods. The soothing effect of amitriptyline usually occurs very quickly, while the mood-improving effect begins after about two weeks of regular use.

Chronic pain often interferes with the processing of pain signals in the brain. The messenger serotonin plays a major role in building a filter for incoming pain signals. By influencing serotonin, amitriptyline can replace the constant use of painkillers. The active ingredient must be taken for pain relief but then regularly over a long period of time.

Potential Amitriptyline side effects may include:

Amitriptyline used to treat the following diseases:

  1. Valerie S. Scott says:
    5.0 rating

    Amitriptyline for A headache; Depression

    I took the amitriptyline for about 1 month. I switched from sertraline to amitriptyline. I am very tired at 50 mg and not really awake, in the morning I should take then 25 mg = 75 mg / day. If you already drive weakness has, it is difficult to get fit and become and stay. Now we try in the evening 50 mg amitriptyline retard and in the morning 50 mg sertraline. Sertraline is more drive-promoting. Promethazine I should take only when needed, but this is not necessary because I am sleeping very well from the amitriptyline. The promethazine has left in the effect and should have been steadily increased in order not to lose the effect , So I feel that. Unfortunately, I have increased from the meds and do not dare to drive a car anymore. Since the amitriptyline still does not help as it should, now the sustained release of it has been prescribed, which slows the release of the drug to the body. But about it I do not really notice anything and will definitely get another medication soon and can almost open a pharmacy and if that helps, the constant change of medis is also not good for the body. Concomitant symptoms of the drug amitriptyline: hearing voices, fatigue / impotence, weight gain, furry taste in the mouth, not driving with the car, pain, nausea, vomiting, digestive problems 24.11.09: that does not stop with the vomiting and diarrhea, headaches are not synonymous away.I probably can not tolerate amytriptilin. Let’s see what the Institute Outpatient Center is doing now. I’ll probably get another drug, duloxetine or again sertraline with promethazine and back to the neurologist for the headache. The question I’m asking now is the transition from amytriptiline to duloxetine if that’s so easy? Will also let my liver values check. Come before me, like a guinea pig. 2.12.09: From tomorrow I start with the Cymbalta (active substance duloxetine) 30 mg in the morning, instead of sertraline and amytriptiline. Promethazine for the night.

  2. Donna R. Herman says:
    2.0 rating

    Amitriptyline for Fibromyalgia; Depression

    I got amitriptyline for my depressive episode and pain therapy at the same time. In small doses, this antidepressant should relieve my pain symptoms and at the same time bring in its mood-enhancing effect. After a short time, I noticed improvement. My pain was getting better, but still very strong. But my mood improved. I was not so aggressive anymore, not so sad anymore, not so self-pitying anymore and sometimes even feeling like going outside after weeks and months of hiding in the house … But the side effects were already extreme. Although in the leaflet weight gain was indicated as an adverse reaction, I continued to decline. I no longer had an appetite, often vomited and had constipation problems. Fatigue and exhaustion were the order of the day. Sometimes I could sleep through 10 hours at a stretch, but not at night! In general, I would recommend the drug but! I only used it because I got a drug that was better tolerated and had fewer side effects

  3. Marjorie D. Mann says:
    3.5 rating

    Amitriptyline for A headache; Pain (chronic)

    I have been taking amitriptyline for chronic tension-type headache for about 2 months now. At this time, I first took 12.5 mg, then was increased to 25 mg for about a week. Side effects included only numbness in the mouth shortly after ingestion, increased sweating and loss of satiety. The latter, however, is so annoying to me that I will probably discontinue the drug soon, especially since so far no success has been achieved.

  4. Jody G. Greenwood says:
    4.0 rating

    Amitriptyline for Pain (chronic)

    Given suspected CRPS type I. After 3 – 4 days of habituation completely painless. In the first week of use: tiredness, fatigue, then symptom-free.

    Side effects: Exhaustion; Fatigue
  5. Evangelina L. Burr says:
    4.5 rating

    Amitriptyline for Fibromyalgia

    Through research here in the network and exchange with those affected, I harbored the suspicion of fibromyalgia. Unfortunately, my family doctor is one of the species that calls this disease non-existent. On my own I went to a rheumatologist, who was also well versed in this area and the suspected diagnosis of fibromyalgia. This has since been confirmed by my pain therapist, an anesthesiologist. However, she considers fibromyalgia just another name for a chronic pain syndrome. I am currently treating her with amitriptyline. First, 10 mg 3 times a day. This had very good effects on the pain, in the initial phase, however, as side effects severe fatigue and depression. The depression subsided on its own, the tiredness remained. I switched to Amitryptiline 25 mg retard once a day to sleep in the evening. Unfortunately, the effect on the pain subsided and the tiredness remained. Now I try 2 x daily Amitryptilin 10 mg and at night the delayed-release tablets with 25 mg. Unfortunately, the effect on the pain is not as good as it was at the beginning, the permanent fatigue makes it difficult for me. I’m lying in bed for at least 12 hours and still feel like being wheeled. At work is so far out of the question, which puts a lot of mental stress on me, because I have fears of the future.

    Side effects: Exhaustion; Fatigue
  6. Dorthy J. Quinney says:
    3.0 rating

    Amitriptyline for A headache

    I take the medication for daily head, back and neck pain. Painkillers did not work anymore. I started with 2 drops and am now 20 years old. Finally I can fall asleep in the evening and sleep in about 6 hours. The head, back and neck pain has fallen sharply. I am even free of pain on a daily basis. On pain days I can bear the headache and am able to work. After taking Amitriptyline I feel dry mouth and an unpleasant taste on the tongue. However, these symptoms do not last long and I can live with it well. I have difficulty with weight gain, which is extreme. But I prefer a few pounds heavier than daily with KOpfschmerzen to live.

  7. Nikita K. Adkins says:
    3.0 rating

    Amitriptyline for Migraine; Sleep disorders; Depression

    The drug has hit me very well in my sleep disorders and as a migraine prophylaxis after a good 2 weeks, but I have to say, only when my doctor transferred me to the 25 retard, from which I take to night 2, am. From the film-coated tablets I had a terrible metallic taste in my mouth after about 1 week and the dry mouth was also very bad. For revenue of retardtabl. I do not have that anymore. The only terrible thing is the steady weight gain that I do not get controlled !!

  8. Vickie S. Davis says:
    2.0 rating

    Amitriptyline for Migraine

    Topiramate: tingling in the hands and feet, weight loss very light, fatigue, amitriptyline: numbness on the tongue, if you take the drops undiluted .. Tip: dissolve in water.

    Side effects: Loss in weight; Fatigue
  9. Frederick M. Darnall says:
    2.5 rating

    Amitriptyline for Pain (chronic)

    Have lost a lot of hair with taking amitriptyline over the years. Approximately Four weeks after discontinuation of amitriptyline hair loss went away 🙂 FREU

    Side effects: Hair loss; Increase in weight
  10. Edward E. Doyle says:
    3.5 rating

    Amitriptyline for Pain (chronic)

    Amitriptyline made the pain bearable and at night I was able to sleep well. Constipation occurred immediately and weight gain after a few weeks. I am assuming that Ami is now already 4 years old, about half a year after receipt started my hair loss. I went to the doctor and he said it could not be from the Ami. Zig investigations have revealed nothing. Had beautiful natural curls, now I have hardly any hair and the curls you see almost nothing at all. Am super unhappy about it. I dropped off the Ami four days ago and I’m curious how it affects my hair.

  11. Nicole M. Mosley says:
    2.5 rating

    Amitriptyline for Pain (chronic)

    At the beginning dry mouth, extreme fatigue, bloatedness. Then especially weight gain, had to keep constantly strong Diaet and do sports to keep weight reasonably. After about 4 months beginning of severe hair loss, especially after washing your hair (counted 260 hair). I then discontinued the preparation for fear of hair loss. My chron. However, pain (muscle dysbalance with severe muscle pain) caused by an incompetent osteopath (violent, completely senseless straining) has steadily improved with ingestion. Exit due to discontinuation therefore unknown. Hair loss persisted after discontinuing the med. For 3 months and then came to a stop. Hair grows again.

  12. Scott J. Long says:
    4.0 rating

    Amitriptyline for Pain (acute); Depression

    I had to stop taking Amitriptyline with that of Dopduravorher I had the levodop in the same strength as this one, because the wrorge partly worsened, affects the effect that should be achieved, according to the doctor, on the other hand, the side effects. Novalinsulfone, I only take when the pain is unbearable, but they beat me regularly after taking to bed, I take omeprazole longer than the other drugs. Due to my illness history, some herniated discs and already two surgeries, at the time I took Tramal and Tramundin for the pain, my stomach is quite attacked and has not recovered, if I do not take it I’ll be back a day later strong heartburn. in the current composition I have no itchy skin except for the arms and legs.

    Side effects: Itching
  13. Michael A. Mendoza says:
    4.0 rating

    Amitriptyline for Sleep disorders

    Because of the necessary ingestion of strong opiates it came after a long time with me to extreme sleep / sleep disorders for months. In the pain ambulance I was therefore recommended the additional intake of amitryptilin 25mg at bedtime as a sleep aid. The sleep problems subsequently decreased and the dose could be reduced to 12.5 mg (half tablet) after some time. In addition to the fatigue on awakening it comes to an extreme morning dry mouth, which leads to increased susceptibility to necking and dental problems. During the day I have to constantly suck candy to speak. The tablets have a pungent taste and if I do not swallow them with enough water, I get a stomachache.

  14. Walter J. Engle says:
    3.5 rating

    Amitriptyline for Sleep disorders; Depression

    I got amitriptiline because I did not tolerate another drug so well. Constantly had stomach upset and was tired all day. The stomach discomfort since then I am now Amitriptilin subsided. However, every day I have headaches that always occur in between times. A little longer and sometimes shorter. In any case extremely unpleasant. Then there are still vertigo attacks. I always take the tablets before going to sleep. Despite the fact that I’ve been taking them for a while now, I’m not getting very tired of it. I can not sleep with it and sleep through a long time. In the morning I feel like driven by a bus. Have the feeling that my head does not fit through the door. The tiredness runs through the whole day. My family doctor said that everything was normal. However, I feel limited. In the household, in private life (no desire to nothing) and especially bad at work. I do not have a mood-whitening effect. It gets worse because of the side effects.

    Side effects: Stomach pain; Dizziness; Fatigue
  15. Alice B. Davis says:
    3.5 rating

    For almost 8 years I have had severe stomach pains and nausea almost daily (especially in the morning). Now I take this medication for 2 months and it has improved a lot. I’ll take it even longer, but I’m surprised it (unlike all other things) has already made an improvement. I think I tolerate it well, although from time to time dizziness occurs, my nose is often clogged and I have gained some weight (which may also be because I finally enjoy the food again).