Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of its calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.
What is the purpose of this ingredient?
- treat depression
- mild to moderately severe as well as severe to very severe chronic pain as part of a treatment plan such as relieve migraine headaches or fibromyalgia
- Release fear
- Reduce nervousness
- Alleviate Sleep Disorders
This is how Amitriptyline works
Below you will learn more about the fields of application and the mode of action of amitriptyline.
Please also read the information on the drug classes tri- and tetracyclic antidepressants, antidepressants, to which the active ingredient amitriptyline belongs.
Areas of application of the active ingredient amitriptyline
Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of the calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.
The active ingredient can also be used for chronic pain, which often has a mental component, within a therapeutic concept. The pain scale that covers amitriptyline ranges from mild to moderately severe pain to severe to very severe pain. For example, headache in migraine attacks and fibromyalgia (musculoskeletal pain) can be treated with amitriptyline.
For the following application areas of Amitriptyline , in-depth information is available:
- Pain (strong to very strong)
- anxiety disorders
Action of Amitriptyline
Amitriptyline belongs to the active ingredient group of tricyclic antidepressants and also has its mode of action.
All brain nerve reactions are mediated by messengers such as serotonin and norepinephrine. These messenger substances are stored in small vesicles at the nerve endings and are released on excitement of the nerve. In this way they reach other nerves and bind to special binding sites (receptors). The affected nerves then transmit the stimulus signal. Once they have fulfilled their task, the messenger substances are returned to their storage via special transport systems or degraded by enzymes.
Amitriptyline has a dual effect. Once the active ingredient in the brain occupies different binding sites for messenger substances and thus changes the influence of these messengers on the brain metabolism. Secondly, amitriptyline blocks transport substances that return the messengers serotonin and norepinephrine to their storage sites after signal transmission. As a result, serotonin and norepinephrine remain longer at the site of action and their effectiveness increases. Amitriptyline in this way triggers anxiety and tension states and reverses depressive moods. The soothing effect of amitriptyline usually occurs very quickly, while the mood-improving effect begins after about two weeks of regular use.
Chronic pain often interferes with the processing of pain signals in the brain. The messenger serotonin plays a major role in building a filter for incoming pain signals. By influencing serotonin, amitriptyline can replace the constant use of painkillers. The active ingredient must be taken for pain relief but then regularly over a long period of time.