About Amitriptyline

3.5 rating based on 116 ratings
Rating: 3.3 Reviews: 116
About Amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of its calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

What is the purpose of this ingredient?

  • treat depression
  • mild to moderately severe as well as severe to very severe chronic pain as part of a treatment plan such as relieve migraine headaches or fibromyalgia
  • Release fear
  • Reduce nervousness
  • Alleviate Sleep Disorders

This is how Amitriptyline works

Below you will learn more about the fields of application and the mode of action of amitriptyline.
Please also read the information on the drug classes tri- and tetracyclic antidepressants, antidepressants, to which the active ingredient amitriptyline belongs.

Areas of application of the active ingredient amitriptyline

Amitriptyline is prescribed for the treatment of depressive disorders (depression). The active ingredient helps especially with mental health problems, in which a bad mood or fears are in the foreground. It also includes anxiety disorders that also have a negative impact on mood. Because of the calming effect, amitriptyline also helps to combat the illness-related sleep disturbances and should be taken in the evening.

The active ingredient can also be used for chronic pain, which often has a mental component, within a therapeutic concept. The pain scale that covers amitriptyline ranges from mild to moderately severe pain to severe to very severe pain. For example, headache in migraine attacks and fibromyalgia (musculoskeletal pain) can be treated with amitriptyline.

For the following application areas of Amitriptyline , in-depth information is available:

  • depression
  • Pain (strong to very strong)
  • anxiety disorders

Action of Amitriptyline

Amitriptyline belongs to the active ingredient group of tricyclic antidepressants and also has its mode of action.

All brain nerve reactions are mediated by messengers such as serotonin and norepinephrine. These messenger substances are stored in small vesicles at the nerve endings and are released on excitement of the nerve. In this way they reach other nerves and bind to special binding sites (receptors). The affected nerves then transmit the stimulus signal. Once they have fulfilled their task, the messenger substances are returned to their storage via special transport systems or degraded by enzymes.

Amitriptyline has a dual effect. Once the active ingredient in the brain occupies different binding sites for messenger substances and thus changes the influence of these messengers on the brain metabolism. Secondly, amitriptyline blocks transport substances that return the messengers serotonin and norepinephrine to their storage sites after signal transmission. As a result, serotonin and norepinephrine remain longer at the site of action and their effectiveness increases. Amitriptyline in this way triggers anxiety and tension states and reverses depressive moods. The soothing effect of amitriptyline usually occurs very quickly, while the mood-improving effect begins after about two weeks of regular use.

Chronic pain often interferes with the processing of pain signals in the brain. The messenger serotonin plays a major role in building a filter for incoming pain signals. By influencing serotonin, amitriptyline can replace the constant use of painkillers. The active ingredient must be taken for pain relief but then regularly over a long period of time.

Potential Amitriptyline side effects may include:

Amitriptyline used to treat the following diseases:

  1. Maria D. Tyler says:
    1.0 rating

    Amitriptyline for Morbus sudeck

    Since 2005 I took upper med still today but I have increased a lot 2005 59KG till today 2008 73Kg +

    Side effects: Increase in weight
  2. George K. Vestal says:
    3.5 rating

    Amitriptyline for Pain (chronic)

    Tired fatigue at the beginning. Absolutely slowly sneak in and take in the evening. In the first days, the tiredness pulled in until the next morning. Responsiveness was severely limited. After about a week it got better, for the next two weeks it looked like a tablet to fall asleep. After about a quarter of a year, no side effects were felt.

    Side effects: Fatigue
  3. Mary E. Kersey says:
    2.0 rating

    Amitriptyline for Pain (acute)

    when taking more than 50mg per evening: severe restlessness in the arms and legs despite great fatigue.

    Side effects: Unrest
  4. Jennifer T. Burris says:
    4.0 rating

    Amitriptyline for Arthrosis; Fibromyalgia

    The diagnosis of fibromyalgia came to my other illnesses 3 weeks ago, and with it the drug amitriptyline. My doctor treating me for the other diseases does not think either of the fibromyalgia or of the drug (he is a surgeon), he says, which intensifies antidepressants I do not feel that way. The infusions and the injections I get in the change every 2 days and just as long holds its effect. Only the tilidine I need right now. Not. The main effect that the extra amitritylin has on me is an infinite tiredness, which my doctor claims could not be, because anti-depressants would make it brightening. Nothing lightens up, but at least I can sleep painless … and that all the time …. oh yes, I can always eat, if I’m not too tired …

    Side effects: Appetite increase; Fatigue
  5. Gary M. Culbreth says:
    3.0 rating

    Amitriptyline for Heart rhythm disturbances; Fibromyalgia

    to ASS Protect 300, I take instead of Marcumar I do not tolerate, carry the Riesiko … amitriptyline, calms me something takes me a little afraid of Vorhafflimmern … now without insulin I could not live anymore but it is not so easy to measure at every meal, inject and then it does not matter, because cortisone that I need for the treatment of colitis makes everything unpredictable again … The sentence Marcumar anybody who my doctors can handle so loud, I can no longer hear muscle cramps , Muscle failure, dyspnea, laryngeal swelling, dizziness, nausea, weakness, heatwaves … all came with the use of Marcumar … after weaning disappeared a large part of the side effects, a renewed trial yielded the same result only a pity that not all with taking the drug occurring Side effects disappeared …

    Side effects: No side effects
  6. Carol D. Randle says:
    4.0 rating

    Amitriptyline for Heart rhythm disturbances

    I have been in anxiety for 30 years. Since I take the drug (15 drops daily) have improved my anxiety. Also my sad moods have improved, can also fall asleep very well. Side effect: burning and bursting of the tongue, Belzig, often dizziness after taking medication, sometimes drowsiness. Tip: take medication in conjunction with apple juice Relieves the Belzige feeling. The drops with a little apple spritzer and drink, then rinse again with apple spritzer. So it works for me. Best regards Marion

    Side effects: Dizziness
  7. Alice F. Reynolds says:
    1.5 rating

    Amitriptyline for Arthrosis; Nerve damage; Sleep disorders

    In Tetrazepam is given after a short time a dependence which refers to the physical level and has nothing to do with the psyche here utmost care is required.

  8. Traci I. Tackett says:
    3.5 rating

    Amitriptyline for Neuralgia

    Strong weight gain of almost 10kg. The same weight for years before use. After taking then constant increase..Medicine otherwise good in effect.

    Side effects: Increase in weight
  9. Vera J. Brennan says:
    3.0 rating

    Amitriptyline for Neuralgia; Pain (back)

    very forgetful, tired in the morning, gaining weight! These are the side effects of the two medications, but what are you doing to make the pain bearable? My feet burned so much that I seriously considered …. what should I do with my feet? Unfortunately, all medications containing amitriptyline are currently unavailable. I asked the companies and got the answer …… there is no drug to get, so we took the drug out completely. I still have some pills (get the Rectard), but I do not know how it goes without the tablets. Would be glad about experiences of you.

    Side effects: Increase in weight; Fatigue
  10. Nancy M. Roberts says:
    3.5 rating

    Amitriptyline for Post-traumatic stress disorder; Depression

    I take Amitriptyline 75, initially it was 50. After stopping trimipramine, I fell into a severe depressive hole lasting months, the study suggests that Amitryptiline works best on all tricyclics in personality disorders and trauma disorders. So off to the doctor. I am relatively happy with it, the mood is much better than before. I only miss the sleep-inducing effect to this day, meanwhile I even take all the pills of the day at once – namely in the morning.

    Side effects: No side effects
  11. Anthony A. Studdard says:
    2.5 rating

    Amitriptyline for Trigeminal neuralgia

    Have been around 8 weeks amitriptyline 10mg. Does not really help me. Have extreme pain attacks that can last several days. Can not live normally for a long time. I am still very young. Got TN after 4 NNH OPs with a cartilage transplant, after botched Caldwell Luc OP. Only slowly, what that means. Much power

    Side effects: Mouth dryness
  12. Stefanie J. Frawley says:
    4.0 rating

    Amitriptyline for Trigeminal neuralgia

    In the summer of 2007 after an unsuccessful dental procedure I got a trigeminal neuralgia. It was treated with carbamazepine last year (1200mg / day). But unfortunately there was a habituation effect and I had pain despite the maximum dose. After then also a liver damage was determined, I have discontinued the drug with the agreement of the doctor. At some point, the pain subsided and passed. In August of this year then again the horror. From morning to night the worst pain again, I could not speak anymore, did not eat – it was fatal. Again, I went to the doctor and this time I was prescribed an antidepressant called Amitriptyline Neuraxpharm 25 Mg. It struck immediately, but had to dose to 2x25mg. I take them for about 30 days, get along well. The pain is not completely gone, but I can live with the pain that occurs. Side effects, however, are extreme dry mouth, fatigue and slight weight gain. But I can recommend the preparation for trigeminal neuralgia as an alternative. Also got gabapentin at the beginning of neuralgia, which has not struck. I hope that soon the story calms down and I can sell the pills.

  13. Willie D. Gonzales says:
    3.5 rating

    Amitriptyline for Pain (back)

    Since I got this stuff, (psychologists), I feel no better. I would rather say the opposite. An internal tremor and dizziness, stomach upset, dry mouth and a pathetic taste have come to it. In addition, you can not just settle it as you have taken it.

    Side effects: Dizziness; Mouth dryness
  14. Jonathan R. Manning says:
    3.0 rating

    Amitriptyline for Depression

    Take Tafil for over 10 years (05, mg – 1.0 mg), was rather sporadic until a year ago and sometimes could get along for a few days. When my mother died a year ago, the anxiety and depression became worse, since then I take it daily, the amount is not higher (0.5mg – 1.0mg). I walk on the treadmill almost every day for at least 1 hour, which is also very helpful. I often feel tired and dizzy, whether it is side effects or the disease itself I can not say.

    Side effects: Dependence