What side effects can Glimepiride have?
Below you will find the most important information about possible known side effects of Glimepiride.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Rare side effects:
Hypersensitivity reaction with itching, hives, rash; Skin hypersensitivity to UV and sun rays, blurred vision, nausea, vomiting, stomach pressure, bloating, abdominal pain, diarrhea, reduction in platelet count.
Very rare side effects:
Changes in blood cell count.
Isolated side effects:
jaundice, gall bladder, hepatitis, liver damage, elevation of liver function, anemia, sodium deficiency; severe hypersensitivity reactions such as shortness of breath, drop in blood pressure, shock; Vascular inflammations, allergic rhinitis, facial swelling.
Side effects without frequency:
hypuriasis with cravings, tremors, restlessness, irritability, difficulty concentrating, confusion, headache, depressed mood, dizziness, listlessness, fatigue, insomnia, helplessness, delirium, superficial breathing, slowing of the heartbeat, Paralysis, sensory disturbances, speech disorders, sweating; cool, moist skin; Anxiety, tachycardia, high blood pressure, heart stumbling, cardiac arrhythmia, heartache (angina pectoris), excretion proliferation.
What interactions does glimepiride show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The hypoglycemic effects of glimepiride may increase ACE inhibitors (hypotension), guanethidine (also an antihypertensive) and quinidine, as well as disopyramide (both antiarrhythmic). The same applies to anabolic steroids, male sex hormones, fenfluramine (an appetite suppressant) and fibrates (high blood lipid levels).
In addition, anti-bacterial agents such as sulfonamides and tetracyclines, quinolones and chloramphenicol and miconazole anti-fungal agents may enhance glimepiride activity. This also applies to anticoagulants as well as cyclophosphamide and ifosphamide (both drugs used in cancer).
Furthermore, the glimepirid effect is enhanced by other blood sugar levels such as insulins and oral antidiabetics. The same applies to agents for depression from the group of MAO inhibitors and serotonin reuptake inhibitors (such as fluoxetine). Pentoxifylline (active ingredient for improving the blood flow properties), non-steroidal anti-inflammatory drugs (group of analgesics) and propafenide (active ingredient for increased uric acid levels) also lead to an increased effect.
The hypoglycemic effect of glimepiride may be attenuated by barbiturates (narcotic and anti-seizure agents), phenothiazines (neuroleptics against agitation and restlessness) and the antiepileptic drug phenytoin. The same applies to diazoxide (active ingredient for hypertension), nicotinic acid (active ingredient for vasodilatation) and dehydrating agents (diuretics).
Female sex hormones, thyroid hormones, glucagon (an anti-hypoglycaemic agent) and laxatives (if misused) may also reduce the effects of glimepiride. This also applies to rifampicin (active substance against tuberculosis), acetazolamide (an ophthalmic agent) and glucocorticoids (anti-inflammatory agents of various causes). But also sympathomimetics (drugs that are used, inter alia, against bronchoconstriction) can also mitigate the effects of glimepiride.
Co-administration of alcohol may exacerbate or attenuate the hypoglycemic effect of glimepiride in an unpredictable manner. The same applies to gastric acid blockers and pentamidine (active substance against certain infectious diseases).
The effect of anticoagulants (anticoagulants) can be strengthened, but also mitigated.