The following provides information on contraindications to the use of Alprazolam in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Alprazolam not be used?
Alprazolam must not be used at:
- Hypersensitivity to alprazolam or other benzodiazepines
- the nerve disease Myasthenia gravis
- history of drug, drug or alcohol dependence
- Severe respiratory dysfunction and sleep pauses (sleep apnea syndrome)
- severe liver dysfunction
- Gait and movement disorders originating from the spinal cord or brain
- acute poisoning with alcohol, sedatives and sleeping pills, analgesics or psychotropic drugs such as neuroleptics, antidepressants and lithium
Careful monitoring is required at
- impaired liver and kidney function
- chronic respiratory disorders
In patients with respiratory disorders, liver and kidney dysfunction, the doctor usually needs to choose a lower dose.
Not all states of tension, excitation and anxiety require drug therapy. Often they are an expression of physical or mental illness and can be influenced by other measures or therapy of the underlying disease.
What should you watch out for during pregnancy and lactation?
Alprazolam and one of its main metabolites reach the unborn baby’s cake. They can accumulate there, which can lead to overdosage in the child resulting in malformations and mental limitations.
If mothers receive benzodiazepines during pregnancy, in high doses or during childbirth during pregnancy, the children may experience withdrawal symptoms such as difficulty breathing, slack muscles, decreased body temperature and poor drinking. Therefore, alprazolam should only be used during pregnancy if the doctor considers it necessary.
Alprazolam and its metabolites pass into breast milk. Since alprazolam is broken down much more slowly in newborns than by children or adults, it causes respiratory problems and dehydration. So it should not be breastfed or weaned when treated with Alprazolam.
What should be considered in children?
The active substance alprazolam is not approved for use in children and adolescents below the age of 18 years.
Warnings and Precautions
- Loss of efficacy (tolerance) may occur after ingestion for several weeks.
- Proper use of the drug can also lead to physical and emotional dependence.
- Patients with liver and kidney disorders and respiratory problems usually require a lower dosage.
- The use of the drug must be stopped at a slowly reduced dosage to avoid withdrawal symptoms.
- Treatment should be as short as possible and should include, including
gradual weaning, do not exceed eight to twelve weeks.
- After using the medicine, ensure that you have sufficient sleep time to avoid memory loss.
- In case of adverse reaction to the medication (restlessness, aggression, irritability) the treatment should be stopped by the doctor.
- The drug is not suitable as a first-line drug for psychosis.
- Treating depression with the drug alone can increase suicidal tendencies.
- The drug may increase the risk of falling, especially in elderly patients.
- The ability to react may be so impaired by the active substance that driving or risky activities should be avoided. This is especially true in conjunction with alcohol.
- Disturbances of concentration and responsiveness are possible even in the morning after taking the drug.
Sometimes medications release allergic reactions.
If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.