Allopurinol contraindications and warnings


Following is information on contraindications to the use of allopurinol in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Allopurinol not be used?

In the case of hypersensitivity to allopurinol, the active substance should not be used. Due to the high active ingredient content, tablets containing more than 300 milligrams of allopurinol should not be used in children or patients with impaired kidney or liver function.

What should you watch out for during pregnancy and lactation?

There is little experience in human use during pregnancy. When very high doses were administered, animal studies revealed malformations in the unborn child. Therefore, Allopurinol should not be used during pregnancy.

Because allopurinol passes into breast milk, lactating women should not take allopurinol.

What should be considered in children?

For children, the daily dose is 10 milligrams of allopurinol per kilogram of body weight, divided into three single doses. No more than 400 milligrams of the active ingredient may be given in one day.

Warnings and Precautions

  • Patients with impaired renal function, liver function or blood disorders should be carefully monitored by the physician.
  • When taking the medicine, ensure that you have plenty of fluids. Especially when treating a gout kidney and uric acid stones, at least two liters of urine must be excreted during the day.
  • The medicine should not be used for the treatment of an acute gout attack.
  • In case of hypersensitivity reactions, fever, burning eyes, difficulty in swallowing and skin damage to the trunk, discontinue use immediately and consult a doctor.
  • Reactivity may be impaired by the drug to the extent that driving a car and operating machinery are dangerous.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.