About Allopurinol

3.5 rating based on 32 ratings
Rating: 3.3 Reviews: 32
About Allopurinol

his active substance is preferably used in the long-term treatment of gout and for the prevention of acute gout attacks. Allopurinol is used to reduce elevated levels of uric acid in the blood (hyperuricemia), when dietary changes, alcohol abstinence and calorie restriction in overweight alone are not enough.

What is the purpose of this ingredient?

    • Lower uric acid concentration in hyperuricemia and gout

Prevent acute attacks of gout

  • Prevent kidney damage in hyperuricemia
  • Prevent Kidney Damage in Leukemia Therapy
  • congenital enzyme deficiency diseases treat


This is how Allopurinol works

Below you will learn more about the fields of application and the mode of action of Allopurinol.
Please also read the information on the drug group Gouting Agents,
to which the active ingredient allopurinol belongs.

Application of the active substance allopurinol

This active substance is preferably used in the long-term treatment of gout and for the prevention of acute gout attacks. Allopurinol is used to reduce elevated levels of uric acid in the blood (hyperuricemia), when dietary changes, alcohol abstinence and calorie restriction in overweight alone are not enough.

During treatment with the drug deposits of uric acid (urate crystals) are dissolved and excreted through the kidney. These deposits are responsible for the typical symptoms of gout.

In children, leukemia may cause kidney damage due to increased levels of uric acid in the blood. For prevention, leukemia therapy is therefore supplemented by allopurinol. Certain hereditary diseases, such as Lesch-Nyhan syndrome leading to childhood gout or adenosine phosphoribosyltransferase deficiency, require the administration of allopurinol.

For the following application areas of Allopurinol , in-depth information is available:

  • gout

Action of Allopurinol

Allopurinol belongs to the active ingredient group of the gout. Gout is a condition in which the concentration of uric acid in the body is excessive. Because uric acid is already poorly soluble in water anyway, crystals that form in the tissue form at too high a concentration. They cause painful inflammation and thickening, especially at the joints.

Uric acid is produced from purines, organic compounds that are mainly found in proteins. Purines are produced by the body itself, but also enter the metabolism with food, especially through protein-rich products such as offal, meat and fish.

The conversion of purines into uric acid is mainly caused by the enzyme xanthine oxidase. Allopurinol inhibits this enzyme and thus lowers the uric acid concentration in the blood. During the intake of Allopurinol less uric acid and more of one of its precursors, the water-soluble hypoxanthine, is formed. Unlike uric acid, the body can easily excrete hypoxanthine through the kidneys with urine.

In addition to purine degradation, allopurinol in some patients inhibits neoplasm of purines directly by blocking the enzyme involved. Indirectly, however, allopurinol limits pathological purine formation: The hypoxanthine that accumulates during treatment with allopurinol inhibits an enzyme that is essential for the first step of purine production in the body.

A moderate, well-balanced diet with plenty of fluid, but possibly without fish, pulses, offal and alcohol, supports treatment with allopurinol. Weight loss may also positively affect uric acid levels in addition to allopurinol therapy.

Potential Allopurinol side effects may include:

Allopurinol used to treat the following diseases:

  1. Arthur S. Bridges says:
    5.0 rating

    Allopurinol for Hyperuricemia

    Allopurinol is supposed to work slowly, so I can not say anything about faster improvement. After a few days, however, the joint pain disappeared and did not reappear. The side effects are, however, strong: The doctor first prescribed 300mg / day, I could not hold out for more than 5 days (tried several times), because of the ever-increasing dizziness and overall feeling as the next day after a long binge drinking: Maul stomach, word-finding problems, Concentration difficulties, slight headache (but still tolerable). The symptoms prohibit actually after three days of driving. I then switched to the 100mg tablets and quartered them to minimize the side effects. I still feel it, but keep it at a tolerable level. The joint pain can be dampened by this, but not as completely prevented as with the higher doses. So I have to pay close attention to my diet to avoid the joint pain and it raises the question of whether the low success with allopurinol counteracts the side effects.

    Side effects: Headache; Dizziness
  2. Andrew J. Johnson says:
    3.0 rating

    Allopurinol for Gout

    After about 2 months of taking Allopurinol, I noticed that I could hardly concentrate at all. I had severe word problems and sometimes dizziness. Is deposed.

    Side effects: Dizziness
  3. David C. Coffee says:
    4.0 rating

    Allopurinol for Gout

    After a few months of taking allopurinol, a feeling of dizziness turned up – especially after getting up. After stopping allopurinol, the dizziness disappeared after a few days. HA says that there is no alternative to allopurinol. Now try to suppress the gout by strict diet.

    Side effects: Dizziness
  4. Joseph S. Stanley says:
    4.5 rating

    Allopurinol for Hyperuricemia

    Significant muscle spasms throughout the body, heart complaints, skin piercing and -ausschlag. It took four days for the symptoms to subside. A later retry with Allopurinol 100 showed the same symptoms.

  5. Julie G. Castile says:
    2.0 rating

    Allopurinol for Gout

    My mother-in-law was prescribed this medicine because of aching limbs (feet), in less than 2 weeks my mother became more and more tired and complained of a twitching in the right eyelid. One week later acute skin rash on the body worst on the face. Dandruff-like and totally red-eyed. She also complained of cardiac arrhythmias and sleep disturbances. In my opinion, this drug should be banned because it can cause extreme side effects and even death in different patients taking the drug.

  6. Harold C. Haynes says:
    3.0 rating

    Dress syndrome triggered. 4 weeks hospital stay Damage to the kidney + liver Dialysis required Itching still lasts after 5.5 weeks An evaluation had to be registered. Is on the system. But is wrong

    Side effects: Itching
  7. Kenneth M. Peake says:
    4.0 rating

    Allopurinol for Hyperuricemia

    After several years of taking the side effects described in the leaflet: Rashes, agonizing itching, increase in creatinine (restriction of kidney function) nodules idHaut Introduction to the family doctor: Oh, what’s in the leaflets … Dermatologist1: dito, 2x500g Dexamethasonealbe 2 garkeine information, antiallergic family doctor This is not a side effect of Allopurinol Meanwhile, there is no body on the body, which is not scratched bloody … Privately questioned Internists (3): stop immediately.Exhaust attempt: the damage is back. Family doctor: Immediately take again! The same as before. Deposed without asking HA. Recovery of damages. What does someone do who has no one to protect him from such experiments? He was 88 years old and I still wonder why he was obsessed with gout (which might have occurred in a few years). The doctor I was not yet able to interview, I’m still too angry about so much arrogance and the many weeks missed Lebensqualtiät.

    Side effects: Skin rash; Skin lesions; Itching
  8. Scott W. Lynch says:
    4.0 rating

    Allopurinol for Hyperuricemia

    In the course of the intake, a tormenting itching of the skin developed, which increasingly also showed damage to the skin, such as nodule formation, swelling, redness and dandruff throughout the body. In parallel there is an elevated creatinine level. After discontinuation of the drug, the skin has improved significantly, but the itching is not completely subsided.

    Side effects: Skin lesions; Itching
  9. James B. Ruffin says:
    4.0 rating

    Allopurinol for Gout

    No side effects. Uric acid value lowered to normal.

    Side effects: No side effects
  10. Antonio A. Williams says:
    2.0 rating

    Allopurinol for Gout

    No side effects. Gout attacks. especially in the big toe joint stay out.

    Side effects: No side effects