About Allopurinol

3.5 rating based on 31 ratings
Rating: 3.3 Reviews: 31
About Allopurinol

his active substance is preferably used in the long-term treatment of gout and for the prevention of acute gout attacks. Allopurinol is used to reduce elevated levels of uric acid in the blood (hyperuricemia), when dietary changes, alcohol abstinence and calorie restriction in overweight alone are not enough.

What is the purpose of this ingredient?

    • Lower uric acid concentration in hyperuricemia and gout

Prevent acute attacks of gout

  • Prevent kidney damage in hyperuricemia
  • Prevent Kidney Damage in Leukemia Therapy
  • congenital enzyme deficiency diseases treat

 

This is how Allopurinol works

Below you will learn more about the fields of application and the mode of action of Allopurinol.
Please also read the information on the drug group Gouting Agents,
to which the active ingredient allopurinol belongs.

Application of the active substance allopurinol

This active substance is preferably used in the long-term treatment of gout and for the prevention of acute gout attacks. Allopurinol is used to reduce elevated levels of uric acid in the blood (hyperuricemia), when dietary changes, alcohol abstinence and calorie restriction in overweight alone are not enough.

During treatment with the drug deposits of uric acid (urate crystals) are dissolved and excreted through the kidney. These deposits are responsible for the typical symptoms of gout.

In children, leukemia may cause kidney damage due to increased levels of uric acid in the blood. For prevention, leukemia therapy is therefore supplemented by allopurinol. Certain hereditary diseases, such as Lesch-Nyhan syndrome leading to childhood gout or adenosine phosphoribosyltransferase deficiency, require the administration of allopurinol.

For the following application areas of Allopurinol , in-depth information is available:

  • gout

Action of Allopurinol

Allopurinol belongs to the active ingredient group of the gout. Gout is a condition in which the concentration of uric acid in the body is excessive. Because uric acid is already poorly soluble in water anyway, crystals that form in the tissue form at too high a concentration. They cause painful inflammation and thickening, especially at the joints.

Uric acid is produced from purines, organic compounds that are mainly found in proteins. Purines are produced by the body itself, but also enter the metabolism with food, especially through protein-rich products such as offal, meat and fish.

The conversion of purines into uric acid is mainly caused by the enzyme xanthine oxidase. Allopurinol inhibits this enzyme and thus lowers the uric acid concentration in the blood. During the intake of Allopurinol less uric acid and more of one of its precursors, the water-soluble hypoxanthine, is formed. Unlike uric acid, the body can easily excrete hypoxanthine through the kidneys with urine.

In addition to purine degradation, allopurinol in some patients inhibits neoplasm of purines directly by blocking the enzyme involved. Indirectly, however, allopurinol limits pathological purine formation: The hypoxanthine that accumulates during treatment with allopurinol inhibits an enzyme that is essential for the first step of purine production in the body.

A moderate, well-balanced diet with plenty of fluid, but possibly without fish, pulses, offal and alcohol, supports treatment with allopurinol. Weight loss may also positively affect uric acid levels in addition to allopurinol therapy.

Potential Allopurinol side effects may include:

Allopurinol used to treat the following diseases:

Disease
Percentage
44%
  1. Patrick S. Bratton says:
    3.5 rating

    Allopurinol for Gout

    My father died the fourth day after taking it, suddenly and completely unexpectedly. According to the doctor, he did not understand, because my father was still fully fit with him in practice. The remedy should never have been prescribed to a 75-year-old man with hypertension. He must have suffered a heart attack during the night due to the drug. I can only say-fingers away from Arcoxia. In the US, this drug is not approved for these reasons!

  2. Meda W. Hart says:
    2.0 rating

    Allopurinol for High blood pressure; Hyperuricemia

    Since 2007, I take Votum Plus, first with a higher water component, but now only 12.5 mg. My blood pressure is now set well. But 2 months after taking it for the first time, I got reactive perforating collagenosis (histologically proven), hyperuricaemia (which may be a side effect of taking the vote, in August 2009 Hashimoto’s thyroiditis was diagnosed with collagenosis, a further autoimmune disease). I’ve had changing stools from diarrhea to constipation for some time, I can not rule out an interaction between all the medications, I also got Tramadol Retard from Ratiopharm, except dizziness, insomnia, extreme skin reaction, nausea, no other side effects but now discontinued because of the dermatitis on the lower legs

    Side effects: Allergic skin reaction
  3. Daniel L. Vue says:
    3.0 rating

    Allopurinol for Gout

    Allpurinol was taken for the first time a few years ago. Already the next day I got a foreskinitis leading to skin detachment. Since I only use the o.g. Drug I put this off. The painfulness went back slowly. This year (2008) another self-test with only a quarter (!) Tablet. Immediately, the inflammation began again. So do not take !! Nobody has described this side effect.

    Side effects: Allergic skin reaction
  4. Charles P. Chaves says:
    2.5 rating

    Allopurinol for Hyperuricemia

    One tablet of Allopurinol 300 was taken once a day for breakfast for the specified period of time and the purine level in the blood was reduced to a normal level of 5.5. After about 4 weeks, however, allergic reactions appeared on the neck and between the fingers on the right hand in the form of itchy, z. T. burning redness and pustules, which fade very slowly after discontinuation of the drug and leave a rough, scaly skin. These side effects were noted a year ago and treated with cortisone ointment, the cause but not related to the drug.

    Side effects: Allergic skin reaction
  5. Robert L. Watkins says:
    3.0 rating

    Allopurinol for Gout

    Massive allergic reaction. After taking a half tablet at 20.oo o’clock the emergency doctor had to come at 2.00 o’clock. The whole body was flushed and the face was so swollen that the eyes could not be opened anymore, in addition breathing difficulties.

    Side effects: Difficulty in breathing
  6. Jonathan G. Dickson says:
    3.5 rating

    Allopurinol for High blood pressure; Hyperuricemia

    As a result of the health care reform, at the beginning of the year I was given Nexium Omeprazole 20 instead of Belok-Zok Metoprolol Succinate-1A. As a result, the systole increased from about 130 to around 170 and higher. At the same time, another case of gastroscopy revealed Barrett’s syndrome. The doctor therefore discontinued metoprolol and increased Atacand to 16/12 and to Omneprazole 40. At the beginning of May, I had severe suffocation and panic attacks in the middle of the night, so I had to call the ambulance. Hospitalization with suspected heart attack. However, all investigations showed no findings. But the respiratory distress attacks and above all the terrible death anxiety starting with inner tremor remained. The doctors are helpless. Therefore I went back to the old proven combination of medicine Belok-Zok / Atacand 8/12 and Omneprazole 20 at my own expense. Since then, panic attacks and respiratory distress are improving steadily. I therefore suspect an interaction of double dose acatand and omneprazole. Does anyone have similar experiences, as the shaking (starting in the afternoon after taking Atacand) and occasional anxiety still persists.

    Side effects: Difficulty in breathing
  7. Jesus T. Acevedo says:
    3.5 rating

    Allopurinol for Gout

    I have been taking allopurinol for a few weeks and soon had the expected side effects, most notably persistent diarrhea. My doctor then advised me to supplement the therapy with a Montmorency sour cherry preparation in the form of concentrate and capsules, which helps very well. Now we have lowered the dosage with allopurinol and the urinary levels have even dropped even further. Diarrhea has been better since then.

    Side effects: Diarrhea
  8. Christopher N. Armijo says:
    3.0 rating

    After taking diarrhea, – even at only half a tablet per day, the intestinal tract was not in order, strong winds and occasionally diarrhea.

    Side effects: Diarrhea
  9. Juan P. Smith says:
    4.0 rating

    Allopurinol for High blood pressure; Hyperuricemia

    Since 2007, I take Votum Plus, first with a higher water component, but now only 12.5 mg. My blood pressure is now set well. But 2 months after taking it for the first time, I got reactive perforating collagenosis (histologically proven), hyperuricaemia (which may be a side effect of taking the vote, in August 2009 Hashimoto’s thyroiditis was diagnosed with collagenosis, a further autoimmune disease). I’ve had changing stools from diarrhea to constipation for some time now

    Side effects: Diarrhea
  10. Kevin S. Cargo says:
    4.0 rating

    After heart attack, too high blood pressure and high uric acid, were prescribed as drugs by the HSK Wiesbaden: bisoprolol 2.5 mg, 100 mg aspirin, lisinopril 10 mg (and allopurinol prescribed only by the family doctor). Ingested for 14 months at age 81 years. Now I have the suspicion that Allopurinol (taken in the evening) could be responsible for the fact that cardiac arrhythmias occurred at night. All medications I have – without asking a doctor – tentatively omitted for several days. Blood pressure has remained unchanged at an average of 125: 75 and pulse 60. Arrhythmias do not seem to occur anymore. If blood pressure rises, I will take medication again.

  11. Bradley A. Levy says:
    3.0 rating

    Allopurinol for Hyperuricemia

    I have been taking allopurinol for a very long time (about 10 years). It significantly lowers my uric acid level. Unfortunately Allopurinol makes me quite tired and tired. For me Allopurinol slightly raises the liver values.

    Side effects: Fatigue
  12. Lynn A. Chin says:
    5.0 rating

    Allopurinol for Gout

    I discontinued Symbicort because the side effects were too blatant for me. My voice has changed, I’ve grown a lot (though doctors deny it, I know), strong and ongoing fatigue. I am very satisfied with the other medications. I also have Nexium mups against acidification of the stomach and cauterization of the esophagus, because I have a stomach wall break, you can not operate and the stomach entrance does not close properly. is also fine, only expensive. Like the Singulair, 100 tablets cost 210 euros, the Nexium costs 99 tablets 125 euros, which makes a great book. Although I get most of the money again, but if you have to anticipate, that’s already steep. But my health is worth the effort and it makes me feel better and life will be worth living, even if you have to live with it for the rest of your life.

    Side effects: Fatigue; Increase in weight
  13. Joshua A. Kibbe says:
    4.5 rating

    Allopurinol for High blood pressure

    Due to the kidney insufficiency, I have more headache (thrusts come daily) nausea, dizzy spells. Much to the toilet. Also at night . One is very often tired, slack, exhausted during the day. Due to the water in my legs (both lower legs) I can not go far. It is very exhausting and your legs hurt a lot. Shrivel kidney left, right is only half kidney still in power. Further degrading. After the name of my doctor, the value was minus 3 until one week ago. Now the value is heading for the 4. (Little shrimp wise) worse.

    Side effects: Fatigue; Headache; Dizziness
  14. Mattie J. Stewart says:
    2.5 rating

    Allopurinol 300 mg after 18 days increased excretion with less urine excretion, constant urinary urgency, headache, drops of urethra

    Side effects: Headache
  15. Kevin J. Vance says:
    4.0 rating

    Allopurinol for Hyperuricemia

    Unexplained, for the time being, itchy skin rash almost all over the body. Duration approx. 6 months. Was over months of dermatologist without success with various cortisone-containing ointments and Atarax tablets, 3pcs / day. treated. But then there was a further deterioration and had to visit the skin clinic in Graz. Was immediately stat. added. Massive treatment over 3 weeks. In the 2nd week UROSIN 300 has been suspected and deposed. Treatment is continued. Gradually, however, there is now an improvement in my condition.

    Side effects: Itching rash
  16. Heather R. Goins says:
    4.0 rating

    after taking the second tablet, began to use an insane reaction, I had to vomit several times, had visual disturbances, got 40 degrees fever and paralel lungs, and on the whole body a rash I looked like blue-blooded, and it itched awfully. After 2 days I came as an emergency in the hospital because my circulation collapsed. I was in intensive for 3 days, and on the monitor, got high-dose cortisone, and antibiotics, Dauerinfusionsen, and various medications. My bludruck dropped to 56/31 After 6 weeks I have everything (almost) behind me, I now look like potatoes, because on the whole body the skin goes off over a large area.

    Side effects: Itching rash
  17. John A. Livingston says:
    4.0 rating

    Allopurinol for Gout

    After taking only 1/2 tablet of Allopurinol AL 100 I developed pustules on the left and right leg within 6 hours, which developed into blister-like, weeping and itchy inflammations within 24 hours. Have the tablets discontinued immediately and go to the doctor tomorrow, after 4 days, no reverse development of the inflammation has begun.

    Side effects: Itching rash
  18. Christopher T. Kelly says:
    3.0 rating

    Allopurinol for Hyperuricemia

    I took Allopurinol for about 7 weeks to lower the uric acid level. The goal was achieved even though I discontinued the drug prematurely. During the time of ingestion, I gained about 12 kg in weight. There were sleep disturbances, but they were not due to allopurinol (I suspect it’s because of terrorization through a youth gait). For sleep and anxiety disorders Solian was prescribed after about 6 weeks. On the 5th day, the sports showed signs of paralysis in the arms and shortness of breath. However, treatment was not required since the inevitable following resting state led to the termination of these side effects. The side effects of allopurinol are documented, but they did not occur without Solian. I therefore suspect that this is a synergy effect. Solian could not prove its effectiveness, so I rated it neutral. I have since discontinued both medications.

  19. Michael A. Bray says:
    1.5 rating

    Allopurinol for High blood pressure; Hyperuricemia

    During the day blood pressure in the range 130 … 145/75 … 90, but extremely susceptible to stress; e.g. during work and in the morning; then briefly (about 20 min.) Blood pressure up to 190/115. Weight gain despite low-fat diet and exercise. No problems with the joints.

    Side effects: Increase in weight