his active substance is preferably used in the long-term treatment of gout and for the prevention of acute gout attacks. Allopurinol is used to reduce elevated levels of uric acid in the blood (hyperuricemia), when dietary changes, alcohol abstinence and calorie restriction in overweight alone are not enough.
What is the purpose of this ingredient?
- Lower uric acid concentration in hyperuricemia and gout
Prevent acute attacks of gout
- Prevent kidney damage in hyperuricemia
- Prevent Kidney Damage in Leukemia Therapy
- congenital enzyme deficiency diseases treat
This is how Allopurinol works
Below you will learn more about the fields of application and the mode of action of Allopurinol.
Please also read the information on the drug group Gouting Agents,
to which the active ingredient allopurinol belongs.
Application of the active substance allopurinol
This active substance is preferably used in the long-term treatment of gout and for the prevention of acute gout attacks. Allopurinol is used to reduce elevated levels of uric acid in the blood (hyperuricemia), when dietary changes, alcohol abstinence and calorie restriction in overweight alone are not enough.
During treatment with the drug deposits of uric acid (urate crystals) are dissolved and excreted through the kidney. These deposits are responsible for the typical symptoms of gout.
In children, leukemia may cause kidney damage due to increased levels of uric acid in the blood. For prevention, leukemia therapy is therefore supplemented by allopurinol. Certain hereditary diseases, such as Lesch-Nyhan syndrome leading to childhood gout or adenosine phosphoribosyltransferase deficiency, require the administration of allopurinol.
For the following application areas of Allopurinol , in-depth information is available:
Action of Allopurinol
Allopurinol belongs to the active ingredient group of the gout. Gout is a condition in which the concentration of uric acid in the body is excessive. Because uric acid is already poorly soluble in water anyway, crystals that form in the tissue form at too high a concentration. They cause painful inflammation and thickening, especially at the joints.
Uric acid is produced from purines, organic compounds that are mainly found in proteins. Purines are produced by the body itself, but also enter the metabolism with food, especially through protein-rich products such as offal, meat and fish.
The conversion of purines into uric acid is mainly caused by the enzyme xanthine oxidase. Allopurinol inhibits this enzyme and thus lowers the uric acid concentration in the blood. During the intake of Allopurinol less uric acid and more of one of its precursors, the water-soluble hypoxanthine, is formed. Unlike uric acid, the body can easily excrete hypoxanthine through the kidneys with urine.
In addition to purine degradation, allopurinol in some patients inhibits neoplasm of purines directly by blocking the enzyme involved. Indirectly, however, allopurinol limits pathological purine formation: The hypoxanthine that accumulates during treatment with allopurinol inhibits an enzyme that is essential for the first step of purine production in the body.
A moderate, well-balanced diet with plenty of fluid, but possibly without fish, pulses, offal and alcohol, supports treatment with allopurinol. Weight loss may also positively affect uric acid levels in addition to allopurinol therapy.