Actos contraindications and warnings


The following provides information on contraindications to the use of pioglitazone in general, pregnancy & breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Pioglitazone not be used?

Pioglitazone must not be given at:

  • Hypersensitivity to this drug
  • Cardiac insufficiency of all states of expression (also in the past)
  • impaired liver function
  • existing bladder cancer, one in history or blood in the urine of unknown cause
  • Acidification of the blood due to an imbalance of the metabolism (diabetic ketoacidosis).

A risk-benefit assessment must be made in the elderly, severe renal impairment and suspected liver damage. This also applies to combination with other blood sugar levels. For patients over the age of 65, physicians must carefully consider the risks of heart failure, bladder cancer, hand, foot, and arm fractures in women for benefit before and during treatment.

The doctor should ask for risk factors for bladder cancer before initiating pioglitazone treatment and clarify any cause of blood in the urine.

What should you watch out for during pregnancy and lactation?

Pioglitazone should not be used during pregnancy or breast-feeding as the safety during pregnancy in humans has not been established and it is not known whether the active substance passes into breast milk. Animal experiments have shown growth retardation of the unborn child as well as a transfer into breast milk.

What should be considered in children?

Pioglitazone should not be used in children and adolescents under the age of 18, as there are not enough results to date for possible risks.

Warnings and Precautions

  • Monthly medical checks on liver enzymes are recommended during the first months of therapy.
  • If jaundice occurs, treatment should be discontinued. In case of nausea, vomiting, upper abdominal discomfort, tiredness, loss of appetite and / or dark urine, the doctor should be consulted immediately.
  • There is weight to be checked regularly.
  • The blood sugar level should be checked regularly.
  • In women who are largely infertile with ovarian cysts, ovulation may be induced by the treatment. This will make pregnancy possible.
  • The drug should not be used with insulin.
  • If the visual acuity is reduced, the ophthalmologist should be consulted, as accumulation of water under the retina may have occurred.
  • If there is blood in the urine, urination problems or increased urination during treatment, seek medical attention immediately.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.