Abilify contraindications and warnings


Following is information on contraindications to the use of aripiprazole in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

When should aripiprazole not be used?

Aripiprazole should not be used in the case of hypersensitivity to the active substance and to psychoses associated with dementia.

Special medical attention and control must be exercised with the active substance at the beginning of the therapy until the patient is well established Condition of the patient improves and at

  • occurrence of suicidal behavior or suicidal ideation
  • Cardiovascular diseases such as myocardial infarction, angina pectoris and cardiac arrhythmias (especially QT conduction disorders)
  • circulatory disorders of the brain
  • low blood pressure or conditions that favor such as dehydration, low blood supply and treatment with antihypertensive drugs
  • Tendency to involuntary and unwanted muscle movement (dyskinesia)
  • Seizures in history or in conditions related to seizures
  • Patients with diabetes (diabetes mellitus), with risk factors for diabetes mellitus (for example, obesity) or a tendency to it in the family, because the administration of the drug can increase the blood sugar content
  • Malfunction of the esophagus due to the risk of pneumonia due to inhalation of ascending gastric juice.


What should you watch for during pregnancy and lactation?

In animal experiments it was not possible to rule out possible disorders of the development of the offspring by the administration of aripiprazole. Therefore, patients should notify their doctor if they become pregnant or are planning to become pregnant during treatment with aripiprazole. Due to insufficient studies in pregnant women, the active substance should not be used during pregnancy unless the doctor estimates the potential benefit higher than the risk for the unborn child.

Mothers who take the drug in the last trimester of pregnancy endanger their newborns by causing side effects such as movement disorders and withdrawal symptoms. These can be in excitement, muscle tension or flaccidity, tremor, drowsiness, dyspnoea or disturbances in food intake. Such newborns must be carefully monitored by a doctor.

Aripiprazole was excreted into the milk in suckling rats. Since it is unknown whether aripiprazole passes into human milk in humans, patients treated with it should not breast-feed while taking aripiprazole.

What should be considered in children?

For children and adolescents, depending on the manufacturer, there is an age limit of 15 to 18 years for therapy. It is always in this age group the patient information to read and the restrictions are to be observed.

Warnings and Precautions

  • The drug is not suitable for treating psychosis in old dementia patients.
  • In case of fever, muscle stiffness and cloudiness of consciousness, the treatment should be stopped immediately and a doctor should be consulted.
  • Diabetics need to keep a close eye on their blood sugar levels while taking the medicine.
  • Although no direct impact on responsiveness has been demonstrated, driving and using machines should be avoided until you are certain that they are not dangerous due to the drug.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.