What side effects can aripiprazole have?
Below you will find the most important information about possible known side effects of aripiprazole.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of adverse reactions may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects: Restlessness, insomnia, anxiety, movement disorder (extrapyramidal disorder), inner restlessness, urge to move, tremors, dizziness, drowsiness, blunting, headache, blurred vision, indigestion, nausea and vomiting , Constipation, saliva overproduction, fatigue.
Uncommon side effects:
Depression, palpitations, drop in blood pressure on body position change.
If signs of tardive dyskinesia occur, such as involuntary twitching and movement of the mouth, tongue or facial muscles, the doctor should reduce the dose of the drug or discontinue treatment.
During treatment with aripiprazole, clinical trials rarely involved a so-called neuroleptic malignant syndrome. This sometimes fatal side effect is characterized by high fever, muscle stiffness, changing states of consciousness, by irregular pulse or blood pressure, palpitations, sweating and cardiac arrhythmias. It can also cause renal and muscle failure.
What interactions does aripiprazole show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Aripiprazole may potentiate the action of certain antihypertensive agents.
Because aripiprazole has a calming effect, caution should be exercised when combined with alcohol or other brain-active substances. It can lead to an increased blunting.
Aripiprazole should be combined with other agents that change the conduction of the heart only very carefully. These substances include those that cause QT prolongation (the malaria remedy quinidine, the antihypertensive drug sotalol, some neuroleptics and antibiotics) or disorders of the mineral balance in the body (dehydrator).
The gastric acid blocker famotidine reduces the absorption of aripiprazole in the body and thus the effect a little.
Quinidine, the neuroleptics fluoxetine and paroxetine, as well as the antifungals itraconazole and ketoconazole and HIV-1 protease inhibitors (against AIDS) inhibit the degradation of aripiprazole and greatly enhance its action. Therefore, the physician should carefully weigh the benefit and risk with appropriate combination of drugs and reduce the aripiprazole dose to about half. After discontinuation of the above-mentioned active substances, the dose of aripiprazole should then be raised again to the dose level before starting the concomitant therapy. The antihypertensive drug diltiazem and the neuroleptic escitalopram, however, only moderately increase the effects of aripiprazole.
The antiepileptic drugs carbamazepine, phenytoin, phenobarbital and primidone promote the breakdown of aripiprazole in the body and reduce its effects so much that the aripirazole dose must be doubled when given together. The same applies to the tuberculosis drugs rifampicin and rifabutin, the HIV drugs efavirenz and nevirapine, as well as to St. John’s wort. After stopping these substances, the doctor should reduce the dosage of aripiprazole to the normal dose.